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MeSH Review

Mood Disorders

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Disease relevance of Mood Disorders


Psychiatry related information on Mood Disorders


High impact information on Mood Disorders

  • Finally, we review the progress accomplished in implicating neurogenesis in hippocampal functioning under physiological conditions and in the development of hippocampal-related pathologies such as epilepsy, mood disorders, and addiction [10].
  • AKT-GSK3beta signaling is a target of lithium and as such has been implicated in the pathogenesis of mood disorders [11].
  • The most characteristic features of bipolar affective disorder (manic-depressive illness) are episodes of mania (bipolar I, BPI) or hypomania (bipolar II, BPII) interspersed with periods of depression [12].
  • Berridge and colleagues suggested that inositol depletion may be the way that lithium works in bipolar affective disorder, but others have suggested that glycogen synthase kinase (GSK3) may be the relevant target [13].
  • Selective antagonism of serotonin (5-hydroxytryptamine, 5HT) and noradrenaline transport by antidepressants is a key element in the 'amine' hypothesis of affective disorders [14].

Chemical compound and disease context of Mood Disorders


Biological context of Mood Disorders


Anatomical context of Mood Disorders


Gene context of Mood Disorders


Analytical, diagnostic and therapeutic context of Mood Disorders


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  3. Distribution, biochemistry and function of striatal adenosine A2A receptors. Svenningsson, P., Le Moine, C., Fisone, G., Fredholm, B.B. Prog. Neurobiol. (1999) [Pubmed]
  4. Tardive dyskinesia in bipolar affective disorder: aging, cognitive dysfunction, course of illness, and exposure to neuroleptics and lithium. Waddington, J.L., Youssef, H.A. The American journal of psychiatry. (1988) [Pubmed]
  5. Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor alpha, in response to deacetylase inhibition by valproic acid and trichostatin A. Reid, G., Métivier, R., Lin, C.Y., Denger, S., Ibberson, D., Ivacevic, T., Brand, H., Benes, V., Liu, E.T., Gannon, F. Oncogene (2005) [Pubmed]
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  7. Lithium ratio in vitro. Diagnosis and lithium carbonate response in psychotic patients. Garver, D.L., Hitzemann, R., Hirschowitz, J. Arch. Gen. Psychiatry (1984) [Pubmed]
  8. Cerebrospinal fluid neurochemistry in children and adolescents with obsessive-compulsive disorder. Swedo, S.E., Leonard, H.L., Kruesi, M.J., Rettew, D.C., Listwak, S.J., Berrettini, W., Stipetic, M., Hamburger, S., Gold, P.W., Potter, W.Z. Arch. Gen. Psychiatry (1992) [Pubmed]
  9. Effect of 5-hydroxytryptophan on serum cortisol levels in major affective disorders. II. Relation to suicide, psychosis, and depressive symptoms. Meltzer, H.Y., Perline, R., Tricou, B.J., Lowy, M., Robertson, A. Arch. Gen. Psychiatry (1984) [Pubmed]
  10. Adult neurogenesis: from precursors to network and physiology. Abrous, D.N., Koehl, M., Le Moal, M. Physiol. Rev. (2005) [Pubmed]
  11. Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Emamian, E.S., Hall, D., Birnbaum, M.J., Karayiorgou, M., Gogos, J.A. Nat. Genet. (2004) [Pubmed]
  12. A genome-wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish. Ginns, E.I., Ott, J., Egeland, J.A., Allen, C.R., Fann, C.S., Pauls, D.L., Weissenbachoff, J., Carulli, J.P., Falls, K.M., Keith, T.P., Paul, S.M. Nat. Genet. (1996) [Pubmed]
  13. A common mechanism of action for three mood-stabilizing drugs. Williams, R.S., Cheng, L., Mudge, A.W., Harwood, A.J. Nature (2002) [Pubmed]
  14. Cloning and expression of a functional serotonin transporter from rat brain. Blakely, R.D., Berson, H.E., Fremeau, R.T., Caron, M.G., Peek, M.M., Prince, H.K., Bradley, C.C. Nature (1991) [Pubmed]
  15. Lithium in the treatment of mood disorders. Stern, R. N. Engl. J. Med. (1995) [Pubmed]
  16. "Serotonin depression"--a biochemical subgroup within the affective disorders? Asberg, M., Thorén, P., Träskman, L., Bertilsson, L., Ringberger, V. Science (1976) [Pubmed]
  17. Affective disorders and S-adenosylmethionine: a new hypothesis. Cantoni, G.L., Mudd, S.H., Andreoli, V. Trends Neurosci. (1989) [Pubmed]
  18. Effects of 1-desamo-8-D-arginine vasopressin on behaviour and cognition in primary affective disorder. Gold, P.W., Weingartner, H., Ballenger, J.C., Goodwin, F.K., Post, R.M. Lancet (1979) [Pubmed]
  19. Linkage of bipolar disorder to chromosome 18q and the validity of bipolar II disorder. McMahon, F.J., Simpson, S.G., McInnis, M.G., Badner, J.A., MacKinnon, D.F., DePaulo, J.R. Arch. Gen. Psychiatry (2001) [Pubmed]
  20. Lithium ion transport and affective disorders within families of bipolar patients. Identification of a major gene locus. Dorus, E., Cox, N.J., Gibbons, R.D., Shaughnessy, R., Pandey, G.N., Cloninger, C.R. Arch. Gen. Psychiatry (1983) [Pubmed]
  21. Body composition in affective disorder before, during, and after lithium carbonate therapy. Colt, E.W., Dunner, D.L., Wang, J., Ross, D.C., Pierson, R.N., Fieve, R.R. Arch. Gen. Psychiatry (1982) [Pubmed]
  22. Patterns of maternal transmission in bipolar affective disorder. McMahon, F.J., Stine, O.C., Meyers, D.A., Simpson, S.G., DePaulo, J.R. Am. J. Hum. Genet. (1995) [Pubmed]
  23. Genetic association between monoamine oxidase A microsatellite and RFLP alleles and bipolar affective disorder: analysis and meta-analysis. Rubinsztein, D.C., Leggo, J., Goodburn, S., Walsh, C., Jain, S., Paykel, E.S. Hum. Mol. Genet. (1996) [Pubmed]
  24. Erythrocyte soluble catechol-O-methyl transferase activity in primary affective disorder. A clinical and genetic study. Gershon, E.S., Jonas, W.Z. Arch. Gen. Psychiatry (1975) [Pubmed]
  25. Increased number of vasopressin- and oxytocin-expressing neurons in the paraventricular nucleus of the hypothalamus in depression. Purba, J.S., Hoogendijk, W.J., Hofman, M.A., Swaab, D.F. Arch. Gen. Psychiatry (1996) [Pubmed]
  26. The effect of lithium treatment on thyroid function in patients with primary affective disorder. Cho, J.T., Bone, S., Dunner, D.L., Colt, E., Fieve, R.R. The American journal of psychiatry. (1979) [Pubmed]
  27. Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dendritic spines. Law, A.J., Weickert, C.S., Hyde, T.M., Kleinman, J.E., Harrison, P.J. The American journal of psychiatry. (2004) [Pubmed]
  28. High levels of Gs alpha in platelets of euthymic patients with bipolar affective disorder. Mitchell, P.B., Manji, H.K., Chen, G., Jolkovsky, L., Smith-Jackson, E., Denicoff, K., Schmidt, M., Potter, W.Z. The American journal of psychiatry. (1997) [Pubmed]
  29. Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress. Müller, M.B., Zimmermann, S., Sillaber, I., Hagemeyer, T.P., Deussing, J.M., Timpl, P., Kormann, M.S., Droste, S.K., Kühn, R., Reul, J.M., Holsboer, F., Wurst, W. Nat. Neurosci. (2003) [Pubmed]
  30. Segregation and linkage studies of plasma dopamine-beta-hydroxylase (DBH), erythrocyte catechol-O-methyltransferase (COMT), and platelet monoamine oxidase (MAO): possible linkage between the ABO locus and a gene controlling DBH activity. Goldin, L.R., Gershon, E.S., Lake, C.R., Murphy, D.L., McGinniss, M., Sparkes, R.S. Am. J. Hum. Genet. (1982) [Pubmed]
  31. Human dopamine D4 receptor gene: frequent occurrence of a null allele and observation of homozygosity. Nöthen, M.M., Cichon, S., Hemmer, S., Hebebrand, J., Remschmidt, H., Lehmkuhl, G., Poustka, F., Schmidt, M., Catalano, M., Fimmers, R. Hum. Mol. Genet. (1994) [Pubmed]
  32. CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study. Luo, X., Kranzler, H.R., Zuo, L., Wang, S., Blumberg, H.P., Gelernter, J. Hum. Mol. Genet. (2005) [Pubmed]
  33. Brain-derived neurotrophic factor (BDNF) in stress and affective disorders. Licinio, J., Wong, M.L. Mol. Psychiatry (2002) [Pubmed]
  34. Prospective multicentre study of pregnancy outcome after lithium exposure during first trimester. Jacobson, S.J., Jones, K., Johnson, K., Ceolin, L., Kaur, P., Sahn, D., Donnenfeld, A.E., Rieder, M., Santelli, R., Smythe, J. Lancet (1992) [Pubmed]
  35. The erythrocyte lithium-plasma lithium ratio in patients with primary affective disorder. Ramsey, T.A., Frazer, A., Mendels, J., Dyson, W.L. Arch. Gen. Psychiatry (1979) [Pubmed]
  36. Cerebral metabolic rates for glucose in mood disorders. Studies with positron emission tomography and fluorodeoxyglucose F 18. Baxter, L.R., Phelps, M.E., Mazziotta, J.C., Schwartz, J.M., Gerner, R.H., Selin, C.E., Sumida, R.M. Arch. Gen. Psychiatry (1985) [Pubmed]
  37. Drug therapy in the prevention of recurrences in unipolar and bipolar affective disorders. Report of the NIMH Collaborative Study Group comparing lithium carbonate, imipramine, and a lithium carbonate-imipramine combination. Prien, R.F., Kupfer, D.J., Mansky, P.A., Small, J.G., Tuason, V.B., Voss, C.B., Johnson, W.E. Arch. Gen. Psychiatry (1984) [Pubmed]
  38. Lithium carbonate in affective disorders. IV. A double-blind study of prophylaxis in unipolar recurrent depression. Fieve, R.R., Dunner, D.L., Kumbarachi, T., Stallone, F. Arch. Gen. Psychiatry (1975) [Pubmed]
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