Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Brown, J. et al.

The effects of repeating a recognition test in lorazepam-induced amnesia: evidence for impaired contextual memory as a cause of amnesia.

In two experiments, a recognition test for an earlier presented list was given twice in immediate succession (Test 1 and Test 2). On the hypothesis that anterograde amnesia for episodic memory involves a deficit in contextual memory, amnesic subjects should confuse familiarity with distractor items gained during Test 1 with familiarity gained during original list presentation. As a result, they should think that they recognize more items on Test 2. This will lower recognition efficiency in Test 2 by increasing false alarms rather than by reducing hits. For subjects with an amnesia induced by lorazepam, but not for control subjects, recognition efficiency was substantially reduced in Test 2 in both experiments. As predicted, this impairment was due to a large increase in false alarms, with no decrease in the number of hits. The impairment could not be explained by a difference in recognition level between lorazepam and control subjects on Test 1. These findings therefore support the contextual memory deficit hypothesis of anterograde amnesia. Their implications for understanding the relationship between recall and recognition in amnesia are discussed.[1]

References

The effects of repeating a recognition test in lorazepam-induced amnesia: evidence for impaired contextual memory as a cause of amnesia. Brown, J., Brown, M.W. The Quarterly journal of experimental psychology. A, Human experimental psychology. (1990) [Pubmed]

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