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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Activation of c-Ki-ras not detectable in adenomas or adenocarcinomas arising in rat pancreas.

The objective of this study was to determine whether activation of c-Ki-ras occurs in carcinogen-induced rat pancreatic tumors. DNAs from 27 samples, which included adenomas, carcinomas in situ, and adenocarcinomas arising in azaserine-treated rats and corn oil-gavaged rats along with a nafenopin-induced rat pancreatic adenocarcinoma were examined for mutation of c-Ki-ras at codons 12, 13, and 61 by using the polymerase chain reaction. Our results indicate that activation of c-Ki-ras is not a common event during pancreatic carcinogenesis in the rat.[1]

References

  1. Activation of c-Ki-ras not detectable in adenomas or adenocarcinomas arising in rat pancreas. Schaeffer, B.K., Zurlo, J., Longnecker, D.S. Mol. Carcinog. (1990) [Pubmed]
 
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