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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Acute onset deafness in a 4-year-old girl after a single infusion of cis-platinum.

Dose-dependent reduction of auditory function mainly in the high frequency range has been described as a common adverse side effect of cis-platinum. Here we report on a 4-year-old girl with osteosarcoma of the right distal femur who developed acute bilateral deafness 3 days after a single infusion of high-dose cis-platinum (150 mg/m2) during preoperative chemotherapy. Sudden disabling ototoxicity should be considered when administering high-dose cis-platinum to young children.[1]


  1. Acute onset deafness in a 4-year-old girl after a single infusion of cis-platinum. Bührer, C., Weinel, P., Sauter, S., Reiter, A., Riehm, H., Laszig, R. Pediatric hematology and oncology. (1990) [Pubmed]
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