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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Localization of phosphatidylinositol signaling components in rat taste cells: role in bitter taste transduction.

To assess the role of phosphatidylinositol turnover in taste transduction we have visualized, in rat tongue, ATP-dependent endoplasmic reticular accumulation of 45Ca2+, inositol 1,4,5-trisphosphate receptor binding sites, and phosphatidylinositol turnover monitored by autoradiography of [3H]cytidine diphosphate diacylglycerol formed from [3H]cytidine. Accumulated 45Ca2+, inositol 1,4,5-trisphosphate receptors, and phosphatidylinositol turnover are selectively localized to apical areas of the taste buds of circumvallate papillae, which are associated with bitter taste. Further evidence for a role of phosphatidylinositol turnover in bitter taste is our observation of a rapid, selective increase in mass levels of inositol 1,4,5-trisphosphate elicited by low concentrations of denatonium, a potently bitter tastant.[1]

References

  1. Localization of phosphatidylinositol signaling components in rat taste cells: role in bitter taste transduction. Hwang, P.M., Verma, A., Bredt, D.S., Snyder, S.H. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
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