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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria.

The inhibitory effect of the dienone-phenolic triterpene, celastrol, on lipid peroxidation in rat liver mitochondrial membranes induced by ADP and Fe2+ was studied. The anti-peroxidative effect of celastrol was very strong: its 50% inhibitory concentration was 7 microM, and it was about 15 times more effective than alpha-tocopherol. Celastrol scavenged 1.5 molar equivalents of radicals in homogeneous aqueous ethanolic solution, whereas cysteine and alpha-tocopherol scavenged one and two molar equivalents of radicals, respectively. The process of anti-peroxidation of celastrol was biphasic, possibly due to stepwise inhibitions of peroxidation in the outer and inner mitochondrial membranes.[1]


  1. The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria. Sassa, H., Takaishi, Y., Terada, H. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
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