Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Sakagami, H. et al.

Hiroshi Sakagami, Tomohiko Matsuta, Kazue Satoh, Sumiko Ohtsuki, Chiyako Shimada, Taisei Kanamoto, Shigemi Terakubo, Hideki Nakashima, Yurika Morita, Atsuko Ohkubo, Tadashi Tsuda, Katsuyoshi Sunaga, Jun Maki, Tomoko Sugiura, Madoka Kitajima, Hiroshi Oizumi, Takaaki Oizumi,

Biological Activity of SE-10, Granulated Powder of Sasa senanensis Rehder Leaf Extract.

BACKGROUND: We have previously reported that alkaline extract of Sasa senanensis leaves (SE) showed potent anti-HIV, anti-UV and radical scavenging activity. In the present study, we investigated the biological activities of SE-10, a granulated powder of SE supplemented with lactose, lactitol, trehalose and tea extract. MATERIALS AND METHODS: Cell viability of mock-infected, HIV-infected, and UV-irradiated cells was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. Scavenging activity of superoxide anion and hydroxyl radicals was determined by electron-spin resonance spectroscopy. Cytochrome P-450 (CYP)3A4 activity was measured by β-hydroxylation of testosterone in human recombinant CYP3A4. RESULTS: SE-10 had slightly higher anti-HIV and anti-UV activities, but slightly lower radical-scavenging and CYP3A4-inhibitory activities, as compared with SE. CONCLUSION: The present study demonstrates that the biological activities of SE were well preserved during the manufacturing process of SE-10.[1]

References

Biological Activity of SE-10, Granulated Powder of Sasa senanensis Rehder Leaf Extract. Sakagami, H., Matsuta, T., Satoh, K., Ohtsuki, S., Shimada, C., Kanamoto, T., Terakubo, S., Nakashima, H., Morita, Y., Ohkubo, A., Tsuda, T., Sunaga, K., Maki, J., Sugiura, T., Kitajima, M., Oizumi, H., Oizumi, T. In. Vivo (2012) [Pubmed]

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