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Shatat, I.F. et al.

Ibrahim F. Shatat, Sherron M. Jakson, Amanda E. Blue, Mary A. Johnson, John K. Orak, Ram Kalpatthi, Sherron M. Jakson, Amanda E. Blue, Mary A. Johnson, John K. Orak, Ram Kalpatthi,

Masked hypertension is prevalent in children with sickle cell disease: a Midwest Pediatric Nephrology Consortium study.

BACKGROUND: The prevalence of hypertension and abnormal blood pressure (BP) patterns on 24-h ambulatory BP monitoring (ABPM) remains unknown in children with sickle cell disease (SCD). METHODS: Thirty-eight asymptomatic children with sickle cell disease (SCD) (12 HbSS receiving routine care, 13 HbSC, and 13 HbSS receiving chronic transfusion therapy) underwent 24-h ABPM. Average clinic BP, demographic and biochemical characteristics were collected. RESULTS: Median age was 13 years (range 11-16), body mass index (BMI) 19.1 kg/m(2) (range 18.2-21.1), and 50% were male. Seventeen subjects (43.6%) had ambulatory hypertension, while 4 (10.3%) were hypertensive based on their clinic BP. Mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) dip were 8.3 ± 5.9% and 14.7 ± 7.6% respectively. Twenty-three subjects (59%) had impaired SBP dipping, 7 (18%) had impaired DBP dipping, and 5 (13%) had reversed dipping. Clinic and ABP classification were modestly correlated (rho = 0.38, P = 0.02). CONCLUSION: Abnormalities in ABP measurements and patterns in children with SCD are prevalent and require more attention from heath care providers. ABPM is a valuable tool in identifying masked hypertension and abnormalities in circadian BP.[1]

References

Masked hypertension is prevalent in children with sickle cell disease: a Midwest Pediatric Nephrology Consortium study. Shatat, I.F., Jakson, S.M., Blue, A.E., Johnson, M.A., Orak, J.K., Kalpatthi, R. Pediatr. Nephrol. (2013) [Pubmed]

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