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Carbon catabolite regulation of phenylacetyl-CoA ligase from Pseudomonas putida.

Phenylacetyl-CoA ligase (PA-CoA ligase) from P. putida U is a newly described enzyme involved in the aerobic catabolism of phenylacetic acid. The enzyme was specifically induced when P. putida was grown in a chemically defined medium containing phenylacetic acid as the sole carbon source. The induction of PA-CoA ligase was delayed by adding easily metabolizable carbon sources to the medium; the effect was more drastic in the presence of glucose. Glucose did not cause catabolic inactivation but rather catabolic repression, this effect being reversed by cAMP.[1]

References

  1. Carbon catabolite regulation of phenylacetyl-CoA ligase from Pseudomonas putida. Martinez-Blanco, H., Reglero, A., Luengo, J.M. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
 
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