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Gene Review

phaE  -  phenylacetate-CoA ligase

Pseudomonas putida KT2440

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Disease relevance of phaE

  • A recombinant strain of Pseudomonas putida, which overexpressed phaE and phaC from T. pfennigii, was used to isolate the PHA synthase by a two-step procedure including chromatography on Procion Blue H-ERD and hydroxyapatite [1].
  • A process for the large-scale production of 4-hydroxyvalerate (4HV)-containing biopolyesters with a new monomer composition was developed by means of high-cell-density cultivation applying recombinant strains of Pseudomonas putida and Ralstonia eutropha, harboring the PHA-biosynthesis genes phaC and phaE of Thiocapsa pfennigii [2].

High impact information on phaE


Chemical compound and disease context of phaE


Biological context of phaE

  • Also, with respect to the molecular organization of phaE and phaC, this region of the T. pfennigii genome resembled very much the corresponding regions of C. vinosum and of Thiocystis violacea [1].

Associations of phaE with chemical compounds


  1. Analysis of the Thiocapsa pfennigii polyhydroxyalkanoate synthase: subcloning, molecular characterization and generation of hybrid synthases with the corresponding Chromatium vinosum enzyme. Liebergesell, M., Rahalkar, S., Steinbüchel, A. Appl. Microbiol. Biotechnol. (2000) [Pubmed]
  2. Development of a process for the biotechnological large-scale production of 4-hydroxyvalerate-containing polyesters and characterization of their physical and mechanical properties. Gorenflo, V., Schmack, G., Vogel, R., Steinbüchel, A. Biomacromolecules (2001) [Pubmed]
  3. Purification and biochemical characterization of phenylacetyl-CoA ligase from Pseudomonas putida. A specific enzyme for the catabolism of phenylacetic acid. Martínez-Blanco, H., Reglero, A., Rodriguez-Aparicio, L.B., Luengo, J.M. J. Biol. Chem. (1990) [Pubmed]
  4. Induction and quantification of phenylacyl-CoA ligase enzyme activities in Pseudomonas putida CA-3 grown on aromatic carboxylic acids. Ward, P.G., O' Connor, K.E. FEMS Microbiol. Lett. (2005) [Pubmed]
  5. Induction and repression of the sty operon in Pseudomonas putida CA-3 during growth on phenylacetic acid under organic and inorganic nutrient-limiting continuous culture conditions. O'Leary, N.D., Duetz, W.A., Dobson, A.D., O'Connor, K.E. FEMS Microbiol. Lett. (2002) [Pubmed]
  6. "In vitro" synthesis of different naturally-occurring, semisynthetic and synthetic penicillins using a new and effective enzymatic coupled system. Martínez-Blanco, H., Reglero, A., Luengo, J.M. J. Antibiot. (1991) [Pubmed]
  7. Design of an enzymatic hybrid system: a useful strategy for the biosynthesis of benzylpenicillin in vitro. Martínez-Blanco, H., Reglero, A., Martín-Villacorta, J., Luengo, J.M. FEMS Microbiol. Lett. (1990) [Pubmed]
  8. Carbon catabolite regulation of phenylacetyl-CoA ligase from Pseudomonas putida. Martinez-Blanco, H., Reglero, A., Luengo, J.M. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
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