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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Cellular radiation dosimetry and its implications for estimation of radiation risks. Illustrative results with technetium 99m-labeled microspheres and macroaggregates.

Radiation absorbed doses at the cellular level were calculated for routine, human lung perfusion examinations after the intravenous injection of technetium 99m-labeled microspheres or macroaggregated albumin. In such studies, more than 90% of these particles are trapped in the precapillary arterioles of the lung, resulting in an extremely inhomogeneous distribution of radionuclide. We used a computer program that accounted for the inhomogeneity of radiopharmaceutical distribution and calculated the dose to individual lung cells. Absorbed doses to individual lung cells were found to vary by a factor of about 30,000. We believe that such findings call for a reevaluation of the justification for dosimetry at the organ level and an examination of the implications of absorbed doses calculated at the cellular level for the estimation of radiation risks.[1]

References

  1. Cellular radiation dosimetry and its implications for estimation of radiation risks. Illustrative results with technetium 99m-labeled microspheres and macroaggregates. Makrigiorgos, G.M., Adelstein, S.J., Kassis, A.I. JAMA (1990) [Pubmed]
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