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Chemical Compound Review

Technetium-96     technetium

Synonyms: Tc 96, AC1L4ZGA, Technetium, isotope of mass 96
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Disease relevance of technetium

  • All patients had macroscopic vertebral metastases at autopsy despite recent normal technetium Tc 99m bone scans and skeletal roentgenograms [1].
  • Technetium scans in the detection of gastrointestinal hemorrhage. Preoperative diagnosis of enteric duplication in an infant [2].
  • One hundred eight-six patients with suspected acute cholecystitis (AC) underwent radionuclide hepatobiliary imaging with technetium Tc 99m iprofenin to assess the ability of this tracer to detect AC [3].
  • Evaluation of hemangiomas with technetium 99m-labeled RBCs. The perfusion-blood pool mismatch [4].
  • Serial roentgenograms and technetium Tc 99m macroaggregated albumin lung scans were done simultaneously in 30 bronchodilator-dependent asthmatic children and young adults during both relative remission and attacks of status asthmaticus [5].

Psychiatry related information on technetium


High impact information on technetium


Chemical compound and disease context of technetium


Biological context of technetium


Anatomical context of technetium


Associations of technetium with other chemical compounds

  • The results of total skeletal scintigraphy with technetium 99m-labeled diphosphonate in 200 patients with biopsy-proven primary cancer demonstrated abnormalities in 114; 57 had normal roentgenograms [31].
  • Movement of the luminal contents was measured by following the movement of technetium 99m-ethylenetriamine-pentaacetic acid that was instilled as a bolus in the splenic flexure [32].
  • Salicylazosulfapyridine transit times from duodenum to cecum were also very similar to simultaneous measurements of transit by scintigraphic monitoring of technetium 99m [33].
  • Ethionamide inhibited the trapping of technetium and organification of iodine at concentrations seen clinically (10(-5) mol/L) [34].
  • To determine whether noninvasive methods, thallium 201 myocardial (Tl) imaging and technetium 99m gated cardiac blood pool scans (GCBPS), could separate the entities, we evaluated radioisotope images of the heart in 13 patients with ischemic, and eight patients with idiopathic congestive CM, and 14 patients with normal hearts [35].

Gene context of technetium

  • In CD26-deficient mice, the severity of AIA was increased as assessed by enhanced technetium uptake and by increased histological parameters of inflammation (synovial thickness and exudate) [36].
  • The better image quality due to the high energy of technetium, the lower radiation dose for patients and personnel, and the short acquisition protocol favor SSTR scintigraphy with (99m)Tc-P829 over (111)In-labeled compounds [37].
  • Relation between technetium 99m-methoxyisobutylisonitrile accumulation and multidrug resistance protein in the parathyroid glands [38].
  • Hyperthyroxinemia with suppressed TSH developed within the first four weeks of IL-2 administration; during this phase, there was no technetium or iodine uptake by the thyroid gland [39].
  • The current (94m)Tc-MIBI experiments parallel previous studies employing (99m)Tc-MIBI, showing essentially identical performance of the two technetium radiotracers and providing biological validation of (94m)Tc-MIBI for PET imaging of multidrug resistance [40].

Analytical, diagnostic and therapeutic context of technetium


  1. Evaluation of bone pain in carcinoma of the lung. Role of the localized false-negative scan. Covelli, H.D., Zaloznik, A.J., Shekitka, K.M. JAMA (1980) [Pubmed]
  2. Technetium scans in the detection of gastrointestinal hemorrhage. Preoperative diagnosis of enteric duplication in an infant. Wilson, J.P., Wenzel, W.W., Campbell, J.B. JAMA (1977) [Pubmed]
  3. Rapid evaluation of acute abdominal pain by hepatobiliary scanning. Freitas, J.E., Gulati, R.M. JAMA (1980) [Pubmed]
  4. Evaluation of hemangiomas with technetium 99m-labeled RBCs. The perfusion-blood pool mismatch. Front, D., Israel, O., Joachims, H., Brown, Y., Eliachar, I. JAMA (1983) [Pubmed]
  5. Technetium Tc 99m macroaggregated albumin lung scans. Use in chronic childhood asthma. Hyde, J.S., Koch, D.F., Isenberg, P.D., Werner, P. JAMA (1976) [Pubmed]
  6. Role of technetium 99m-labeled monoclonal antibody in the management of melanoma patients. Blend, M.J., Ronan, S.G., Salk, D.J., Gupta, T.K. J. Clin. Oncol. (1992) [Pubmed]
  7. Cerebral blood flow in progressive aphasia without dementia. Case report, using 133xenon inhalation, technetium 99m hexamethylpropyleneamine oxime and single photon emission computerized tomography. Delecluse, F., Andersen, A.R., Waldemar, G., Thomsen, A.M., Kjaer, L., Lassen, N.A., Postiglione, A. Brain (1990) [Pubmed]
  8. Transient frontal hypoperfusion in Tc-99m hexamethylpropyleneamineoxime single photon emission computed tomography imaging during alcohol withdrawal. Tutus, A., Kuğu, N., Sofuoğlu, S., Nardali, M., Simşek, A., Karaaslan, F., Gönül, A.S. Biol. Psychiatry (1998) [Pubmed]
  9. Single photon emission computerised tomography in elderly patients with Alzheimer's disease and multi-infarct dementia. Regional uptake of technetium-labelled HMPAO related to clinical measurements. McKeith, I.G., Bartholomew, P.H., Irvine, E.M., Cook, J., Adams, R., Simpson, A.E. The British journal of psychiatry : the journal of mental science. (1993) [Pubmed]
  10. Combined technetium radioisotope penile plethysmography and xenon washout: a technique for evaluating corpora cavernosal inflow and outflow during early tumescence. Schwartz, A.N., Graham, M.M. J. Nucl. Med. (1991) [Pubmed]
  11. Hepatic hemangioma with normal angiograms. Three case reports. Davis, W.D., Ferrante, W.A., Tutton, R.H., Bowen, J.C. JAMA (1990) [Pubmed]
  12. The early diagnosis of common bile duct obstruction using cholescintigraphy. Kaplun, L., Weissmann, H.S., Rosenblatt, R.R., Freeman, L.M. JAMA (1985) [Pubmed]
  13. The role of radioimmunodetection in the management of testicular cancer. Javadpour, N., Kim, E.E., DeLand, F.H., Salyer, J.R., Shah, U., Goldenberg, D.M. JAMA (1981) [Pubmed]
  14. Suctioning of upper airway meconium in newborn infants. Gage, J.E., Taeusch, H.W., Treves, S., Caldicott, W. JAMA (1981) [Pubmed]
  15. Persistence of vacuolated RBCs after splenectomy in adults. Neilan, B.A., Perry, J.F. JAMA (1980) [Pubmed]
  16. Scintigraphic assessment of bowel involvement and disease activity in Crohn's disease using technetium 99m-hexamethyl propylene amine oxine as leukocyte label. Schölmerich, J., Schmidt, E., Schümichen, C., Billmann, P., Schmidt, H., Gerok, W. Gastroenterology (1988) [Pubmed]
  17. Automatic implantable cardioverter/defibrillator discharges and acute myocardial injury. Avitall, B., Port, S., Gal, R., McKinnie, J., Tchou, P., Jazayeri, M., Troup, P., Akhtar, M. Circulation (1990) [Pubmed]
  18. Comparison of ictal SPECT and interictal PET in the presurgical evaluation of temporal lobe epilepsy. Ho, S.S., Berkovic, S.F., Berlangieri, S.U., Newton, M.R., Egan, G.F., Tochon-Danguy, H.J., McKay, W.J. Ann. Neurol. (1995) [Pubmed]
  19. Technetium Tc 99m diphosphonate bone scan. False-normal findings in elderly patients with hematogenous vertebral osteomyelitis. Schlaeffer, F., Mikolich, D.J., Mates, S.M. Arch. Intern. Med. (1987) [Pubmed]
  20. Multicenter trial of sentinel node biopsy for breast cancer using both technetium sulfur colloid and isosulfan blue dye. Tafra, L., Lannin, D.R., Swanson, M.S., Van Eyk JJ, n.u.l.l., Verbanac, K.M., Chua, A.N., Ng, P.C., Edwards, M.S., Halliday, B.E., Henry, C.A., Sommers, L.M., Carman, C.M., Molin, M.R., Yurko, J.E., Perry, R.R., Williams, R. Ann. Surg. (2001) [Pubmed]
  21. Physiological role for cholecystokinin in reducing postprandial hyperglycemia in humans. Liddle, R.A., Rushakoff, R.J., Morita, E.T., Beccaria, L., Carter, J.D., Goldfine, I.D. J. Clin. Invest. (1988) [Pubmed]
  22. Divergent kinetics of 201Tl and 99mTc-SESTAMIBI in cultured chick ventricular myocytes during ATP depletion. Piwnica-Worms, D., Chiu, M.L., Kronauge, J.F. Circulation (1992) [Pubmed]
  23. Outer surface lipoproteins of Borrelia burgdorferi vary in their ability to induce experimental joint injury. Batsford, S., Dunn, J., Mihatsch, M. Arthritis Rheum. (2004) [Pubmed]
  24. Relative glomerular hyperfiltration in primary aldosteronism. Ribstein, J., Du Cailar, G., Fesler, P., Mimran, A. J. Am. Soc. Nephrol. (2005) [Pubmed]
  25. Technetium Tc 99m uptake in postpartum thyrotoxicosis. Lervang, H.H., Askaa, S., Ostergaard Kristensen, H.P. Arch. Intern. Med. (1987) [Pubmed]
  26. Discrepancies between iodine and technetium thyroid scintigraphy. Barth, J.D., Bakker, W.H., Hennemann, G. JAMA (1978) [Pubmed]
  27. Uptake of technetium 99m hepatobiliary imaging agents by cultured rat hepatocytes. Lan, J.A., Chervu, L.R., Johansen, K.L., Wolkoff, A.W. Gastroenterology (1988) [Pubmed]
  28. Quantitative aspects of portal-systemic and arteriovenous shunts within the liver in cirrhosis. Ohnishi, K., Chin, N., Sugita, S., Saito, M., Tanaka, H., Terabayashi, H., Saito, M., Iida, S., Nomura, F., Okuda, K. Gastroenterology (1987) [Pubmed]
  29. Technetium 99m phagocyte scanning in inflammatory bowel disease. Becker, W., Fischbach, W. Gastroenterology (1989) [Pubmed]
  30. Gastric protection by sucralfate. Role of mucus and prostaglandins. Shea-Donohue, T., Steel, L., Montcalm, E., Dubois, A. Gastroenterology (1986) [Pubmed]
  31. Screening for bone metastases. Are only scans necessary? McDougall, I.R., Kriss, J.P. JAMA (1975) [Pubmed]
  32. Association between postprandial changes in colonic intraluminal pressure and transit. Moreno-Osset, E., Bazzocchi, G., Lo, S., Trombley, B., Ristow, E., Reddy, S.N., Villanueva-Meyer, J., Fain, J.W., Jing, J., Mena, I. Gastroenterology (1989) [Pubmed]
  33. Sulfapyridine appearance in plasma after salicylazosulfapyridine. Another simple measure of intestinal transit. Kellow, J.E., Borody, T.J., Phillips, S.F., Haddad, A.C., Brown, M.L. Gastroenterology (1986) [Pubmed]
  34. Ethionamide-induced goitrous hypothyroidism. Drucker, D., Eggo, M.C., Salit, I.E., Burrow, G.N. Ann. Intern. Med. (1984) [Pubmed]
  35. Thallium 201 imaging and gated cardiac blood pool scans in patients with ischemic and idiopathic congestive cardiomyopathy. A clinical and pathologic study. Bulkley, B.H., Hutchins, G.M., Bailey, I., Strauss, H.W., Pitt, B. Circulation (1977) [Pubmed]
  36. Circulating CD26 is negatively associated with inflammation in human and experimental arthritis. Busso, N., Wagtmann, N., Herling, C., Chobaz-Péclat, V., Bischof-Delaloye, A., So, A., Grouzmann, E. Am. J. Pathol. (2005) [Pubmed]
  37. Orbital scintigraphy with the somatostatin receptor tracer 99mTc-P829 in patients with Graves' disease. Burggasser, G., Hurtl, I., Hauff, W., Lukas, J., Greifeneder, M., Heydari, B., Thaler, A., Wedrich, A., Virgolini, I. J. Nucl. Med. (2003) [Pubmed]
  38. Relation between technetium 99m-methoxyisobutylisonitrile accumulation and multidrug resistance protein in the parathyroid glands. Yamaguchi, S., Yachiku, S., Hashimoto, H., Kaneko, S., Nishihara, M., Niibori, D., Shuke, N., Aburano, T. World journal of surgery. (2002) [Pubmed]
  39. Acute thyroid dysfunction (thyroiditis) after therapy with interleukin-2. Vassilopoulou-Sellin, R., Sella, A., Dexeus, F.H., Theriault, R.L., Pololoff, D.A. Horm. Metab. Res. (1992) [Pubmed]
  40. Imaging multidrug resistance P-glycoprotein transport function using microPET with technetium-94m-sestamibi. Bigott, H.M., Prior, J.L., Piwnica-Worms, D.R., Welch, M.J. Molecular imaging : official journal of the Society for Molecular Imaging. (2005) [Pubmed]
  41. Multiple-myeloma bone disease. The comparative effect of sodium fluoride and calcium carbonate or placebo. Kyle, R.A., Jowsey, J., Kelly, P.J., Taves, D.R. N. Engl. J. Med. (1975) [Pubmed]
  42. Technetium Tc 99m-macroaggregated albumin angiography and perfusion. Intra-arterial chemotherapy for neoplasms. Bledin, A.G., Kim, E.E., Haynie, T.P. JAMA (1983) [Pubmed]
  43. Albumin lung/heart ratio change. A simple clinical means of documenting increased pulmonary endothelial permeability to protein. Mishkin, F.S., Niden, A., Kumar, A., Thomas, A., Reese, I.C., Vasinrapee, P. JAMA (1987) [Pubmed]
  44. Pulmonary perfusion defect and bronchial artery collateral blood flow. Neches, W.H., Weiss, F.H., Park, S.C., Lenox, C.C., Zuberbuhler, J.R., Carroll, R.G. JAMA (1977) [Pubmed]
  45. Herpes simplex encephalitis. Clinical Assessment. Whitley, R.J., Soong, S.J., Linneman, C., Liu, C., Pazin, G., Alford, C.A. JAMA (1982) [Pubmed]
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