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New Labdane-Type Diterpenoids and Anti-Inflammatory Constituents from Hedychium coronarium.

Four new labdane-type diterpenoids: hedychicoronarin (1), peroxycoronarin D (2), 7β-hydroxycalcaratarin A (3), and (E)-7β-hydroxy-6-oxo-labda-8(17),12-diene-15,16-dial (4), have been isolated from the rhizomes of Hedychium coronarium, together with 13 known compounds (5-17). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 3, 5, 6, and 10 exhibited inhibition (IC50 values ≤4.52 μg/mL) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 3-6, 10, and 11 inhibited fMLP/CB-induced elastase release with IC50 values ≤6.17 μg/mL. [1]

References

  1. New Labdane-Type Diterpenoids and Anti-Inflammatory Constituents from Hedychium coronarium. Chen, J.J., Ting, C.W., Wu, Y.C., Hwang, T.L., Cheng, M.J., Sung, P.J., Wang, T.C., Chen, J.F. Int. J. Mol. Sci (2013) [Pubmed]
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