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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Zingiberaceae


High impact information on Zingiberaceae


Biological context of Zingiberaceae


Anatomical context of Zingiberaceae


Associations of Zingiberaceae with chemical compounds


Gene context of Zingiberaceae

  • We previously showed that panduratin A isolated from an extract of Kaempferia pandurata (Zingiberaceae) was a strong inhibitor of cyclooxygenase-2 (COX-2) in RAW264.7 cells, suggesting a potential use of panduratin A as an anti-inflammatory agent [19].
  • Tomé and Príncipe: Aframomum danielli (Hook. f.) K [20].
  • Pinostrobin from honey and Thai ginger (Boesenbergia pandurata): a potent flavonoid inducer of mammalian phase 2 chemoprotective and antioxidant enzymes [21].
  • Activity-guided isolation of constituents of Renealmia nicolaioides with the potential to induce the phase II enzyme quinone reductase [22].
  • On the basis of the extremely high QR inducing potency of one of these compounds, pinostrobin (5-hydroxy-7-methoxyflavanone), a bioassay-guided search was conducted which revealed a dietary source of pinostrobin, Boesenbergia pandurata (fingerroot), with extraordinarily high ability to induce mammalian phase 2 detoxication enzymes [21].

Analytical, diagnostic and therapeutic context of Zingiberaceae


  1. Non-phenolic linear diarylheptanoids from Curcuma xanthorrhiza: a novel type of topical anti-inflammatory agents: structure-activity relationship. Claeson, P., Pongprayoon, U., Sematong, T., Tuchinada, P., Reutrakul, V., Soontornsaratune, P., Taylor, W.C. Planta Med. (1996) [Pubmed]
  2. Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from betaA(1-42) insult. Kim, D.S., Park, S.Y., Kim, J.K. Neurosci. Lett. (2001) [Pubmed]
  3. Protective effects of panduratin A against oxidative damage of tert-butylhydroperoxide in human HepG2 cells. Sohn, J.H., Han, K.L., Lee, S.H., Hwang, J.K. Biol. Pharm. Bull. (2005) [Pubmed]
  4. Cytotoxic mechanism of flavonoid from Temu Kunci (Kaempferia pandurata) in cell culture of human mammary carcinoma. Sukardiman, n.u.l.l., Darwanto, A., Tanjung, M., Darmadi, M.O. Clin. Hemorheol. Microcirc. (2000) [Pubmed]
  5. Antiproliferative activity of diarylheptanoids from the seeds of Alpinia blepharocalyx. Ali, M.S., Banskota, A.H., Tezuka, Y., Saiki, I., Kadota, S. Biol. Pharm. Bull. (2001) [Pubmed]
  6. [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin. Kim, S.O., Kundu, J.K., Shin, Y.K., Park, J.H., Cho, M.H., Kim, T.Y., Surh, Y.J. Oncogene (2005) [Pubmed]
  7. Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activation. Chun, K.S., Keum, Y.S., Han, S.S., Song, Y.S., Kim, S.H., Surh, Y.J. Carcinogenesis (2003) [Pubmed]
  8. Suppression of mouse skin tumor promotion and induction of apoptosis in HL-60 cells by Alpinia oxyphylla Miquel (Zingiberaceae). Lee, E., Park, K.K., Lee, J.M., Chun, K.S., Kang, J.Y., Lee, S.S., Surh, Y.J. Carcinogenesis (1998) [Pubmed]
  9. Blockade of nuclear factor-kappaB signaling pathway and anti-inflammatory activity of cardamomin, a chalcone analog from Alpinia conchigera. Lee, J.H., Jung, H.S., Giang, P.M., Jin, X., Lee, S., Son, P.T., Lee, D., Hong, Y.S., Lee, K., Lee, J.J. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  10. Antioxidant and antiinflammatory activities of xanthorrhizol in hippocampal neurons and primary cultured microglia. Lim, C.S., Jin, D.Q., Mok, H., Oh, S.J., Lee, J.U., Hwang, J.K., Ha, I., Han, J.S. J. Neurosci. Res. (2005) [Pubmed]
  11. A water extract of Curcuma longa L. (Zingiberaceae) rescues PC12 cell death caused by pyrogallol or hypoxia/reoxygenation and attenuates hydrogen peroxide induced injury in PC12 cells. Koo, B.S., Lee, W.C., Chung, K.H., Ko, J.H., Kim, C.H. Life Sci. (2004) [Pubmed]
  12. Suppressive effect of natural sesquiterpenoids on inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) activity in mouse macrophage cells. Lee, S.K., Hong, C.H., Huh, S.K., Kim, S.S., Oh, O.J., Min, H.Y., Park, K.K., Chung, W.Y., Hwang, J.K. J. Environ. Pathol. Toxicol. Oncol. (2002) [Pubmed]
  13. Seasonal variation and analgesic properties of different parts from Curcuma zedoaria Roscoe (Zingiberaceae) grown in Brazil. Pamplona, C.R., de Souza, M.M., Machado, M.d.a. .S., Cechinel Filho, V., Navarro, D., Yunes, R.A., Delle Monache, F., Niero, R. Z. Naturforsch., C, J. Biosci. (2006) [Pubmed]
  14. Protective effect of curcuminoids on epidermal skin cells under free oxygen radical stress. Bonté, F., Noel-Hudson, M.S., Wepierre, J., Meybeck, A. Planta Med. (1997) [Pubmed]
  15. In vitro anti-inflammatory activity of panduratin A isolated from Kaempferia pandurata in RAW264.7 cells. Yun, J.M., Kwon, H., Hwang, J.K. Planta Med. (2003) [Pubmed]
  16. Antioxidative and antitumor promoting effects of [6]-paradol and its homologs. Chung, W.Y., Jung, Y.J., Surh, Y.J., Lee, S.S., Park, K.K. Mutat. Res. (2001) [Pubmed]
  17. Three non-phenolic diarylheptanoids with anti-inflammatory activity from Curcuma xanthorrhiza. Claeson, P., Panthong, A., Tuchinda, P., Reutrakul, V., Kanjanapothi, D., Taylor, W.C., Santisuk, T. Planta Med. (1993) [Pubmed]
  18. Anti-inflammatory cyclohexenyl chalcone derivatives in Boesenbergia pandurata. Tuchinda, P., Reutrakul, V., Claeson, P., Pongprayoon, U., Sematong, T., Santisuk, T., Taylor, W.C. Phytochemistry (2002) [Pubmed]
  19. Induction of apoptosis by Panduratin A isolated from Kaempferia pandurata in human colon cancer HT-29 cells. Yun, J.M., Kwon, H., Mukhtar, H., Hwang, J.K. Planta Med. (2005) [Pubmed]
  20. Essential oil composition and antimicrobial activity of three Zingiberaceae from S.Tomé e Príncipe. Martins, A.P., Salgueiro, L., Gonçalves, M.J., da Cunha, A.P., Vila, R., Cañigueral, S., Mazzoni, V., Tomi, F., Casanova, J. Planta Med. (2001) [Pubmed]
  21. Pinostrobin from honey and Thai ginger (Boesenbergia pandurata): a potent flavonoid inducer of mammalian phase 2 chemoprotective and antioxidant enzymes. Fahey, J.W., Stephenson, K.K. J. Agric. Food Chem. (2002) [Pubmed]
  22. Activity-guided isolation of constituents of Renealmia nicolaioides with the potential to induce the phase II enzyme quinone reductase. Gu, J.Q., Park, E.J., Vigo, J.S., Graham, J.G., Fong, H.H., Pezzuto, J.M., Kinghorn, A.D. J. Nat. Prod. (2002) [Pubmed]
  23. Anti-tumor promoting potential of naturally occurring diarylheptanoids structurally related to curcumin. Chun, K.S., Sohn, Y., Kim, H.S., Kim, O.H., Park, K.K., Lee, J.M., Moon, A., Lee, S.S., Surh, Y.J. Mutat. Res. (1999) [Pubmed]
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