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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Antineoplastic agents, 107. Isolation of acteoside and isoacteoside from Castilleja linariaefolia.

The southwestern Indian paintbrush, Castilleja linariaefolia, yielded extracts that displayed in vivo activity against murine P-388 (PS) lymphocytic leukemia. Separation guided by PS cell line inhibition led to isolation of cytotoxic compounds that were identified as the known glycosides acteoside [1] (ED50 2.6 micrograms/ml) and isoacteoside [2] (ED50 10 micrograms/ml). The identifications were established by spectral measurements and degradation studies. Mannitol was also found in this plant.[1]

References

  1. Antineoplastic agents, 107. Isolation of acteoside and isoacteoside from Castilleja linariaefolia. Pettit, G.R., Numata, A., Takemura, T., Ode, R.H., Narula, A.S., Schmidt, J.M., Cragg, G.M., Pase, C.P. J. Nat. Prod. (1990) [Pubmed]
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