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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D.

The magnesium transporter 1 (MAGT1) is a critical regulator of basal intracellular free magnesium (Mg(2+)) concentrations. Individuals with genetic deficiencies in MAGT1 have high levels of Epstein-Barr virus (EBV) and a predisposition to lymphoma. We show that decreased intracellular free Mg(2+) causes defective expression of the natural killer activating receptor NKG2D in natural killer (NK) and CD8(+) T cells and impairs cytolytic responses against EBV. Notably, magnesium supplementation in MAGT1-deficient patients restores intracellular free Mg(2+) and NKG2D while concurrently reducing EBV-infected cells in vivo, demonstrating a link between NKG2D cytolytic activity and EBV antiviral immunity in humans. Moreover, these findings reveal a specific molecular function of free basal intracellular Mg(2+) in eukaryotic cells. [1]

References

  1. Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D. Chaigne-Delalande, B., Li, F.Y., O'Connor, G.M., Lukacs, M.J., Jiang, P., Zheng, L., Shatzer, A., Biancalana, M., Pittaluga, S., Matthews, H.F., Jancel, T.J., Bleesing, J.J., Marsh, R.A., Kuijpers, T.W., Nichols, K.E., Lucas, C.L., Nagpal, S., Mehmet, H., Su, H.C., Cohen, J.I., Uzel, G., Lenardo, M.J. Science (2013) [Pubmed]
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