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MeSH Review:

Epstein-Barr Virus Infections

Anagnostopoulos, I. et al., Takimoto, T. et al., López, R. et al., Henderson, E.E. et al., Herbst, H. et al.

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Disease relevance of Epstein-Barr Virus Infections

Similarly, an association between IL-10 expression and EBV-infection of tumor cells was found in AIDS-related malignant non-Hodgkin lymphomas (ARL) [1].

High impact information on Epstein-Barr Virus Infections

Additional screening of 123 oropharyngeal mucosa samples from patients without evidence of acute EBV-infection, using the polymerase chain reaction for EBV-DNA detection combined with EBER- and BHLF1-ISH showed single latently infected lymphocytes in only one case [2].
Beginning at 24 h, and at later times following EBV-infection, cellular transformation became more resistant to the cytotoxic effects of DMS and, in contrast, more sensitive to the cytotoxic effects of MNNG [3].
It is probable that tegument BNRF1/p140 protein is involved in EBV-invasion of target cells, since anti-p140 antibodies inhibit EBV-infection of B-lymphocytes and there is evidence that part of the protein is located on virus surface [4].
To establish EBV-infection in the nasopharyngeal epithelial cells, we carried out cell fusion of the lymphocytes with nasopharyngeal epithelial cells, and proved that it was possible to detect the appearance of EBNA in the epithelial nuclei [5].

References

Frequent expression of interleukin-10 by Epstein-Barr virus-harboring tumor cells of Hodgkin's disease. Herbst, H., Foss, H.D., Samol, J., Araujo, I., Klotzbach, H., Krause, H., Agathanggelou, A., Niedobitek, G., Stein, H. Blood (1996) [Pubmed]
Morphology, immunophenotype, and distribution of latently and/or productively Epstein-Barr virus-infected cells in acute infectious mononucleosis: implications for the interindividual infection route of Epstein-Barr virus. Anagnostopoulos, I., Hummel, M., Kreschel, C., Stein, H. Blood (1995) [Pubmed]
Studies on chemical carcinogen enhancement of Epstein-Barr virus induced transformation of human neonatal and adult peripheral blood lymphocytes. Henderson, E.E., Fronko, G. Int. J. Cancer (1984) [Pubmed]
A B-lymphocyte binding peptide from BNRF1 induced antibodies inhibiting EBV-invasion of B-lymphocytes. López, R., Urquiza, M., Patino, H., Suárez, J., Reyes, C., Patarroyo, M.A., Patarroyo, M.E. Biochimie (2005) [Pubmed]
Establishment of Epstein-Barr virus (EBV) infection in epithelial cells derived from the nasopharynx by cell fusion. Takimoto, T., Morishita, K., Furukawa, M., Umeda, R., Hatano, M. The Journal of laryngology and otology. (1983) [Pubmed]

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