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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Retinal S-antigen epitopes in vertebrate and invertebrate photoreceptors.

Monoclonal antibodies specific for the retinal S-antigen were obtained by hybridization of spleen cells from a BALB/c mouse immunized with bovine S-antigen and NS-1 myeloma cells. Five selected antibodies specifically labeled the photoreceptor cells of the retina by immunofluorescence. Whereas antibody S9E2 only reacted with bovine S-antigen, the other antibodies showed interspecies cross-reactivity. They were used for the characterization of specific epitopes of S-antigen in photoreceptors from a wide range of species representative of various classes of vertebrates and invertebrates. The presence of S-antigen in distant species (vertebrates, Amphioxus, nemerteans, annelids, molluscs) indicates a high phylogenetic stability and suggests an important role for this protein in photoreceptor function.[1]


  1. Retinal S-antigen epitopes in vertebrate and invertebrate photoreceptors. Mirshahi, M., Boucheix, C., Collenot, G., Thillaye, B., Faure, J.P. Invest. Ophthalmol. Vis. Sci. (1985) [Pubmed]
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