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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Birchmeier, C. et al.

ras proteins can induce meiosis in Xenopus oocytes.

Injection of human H-ras protein induces maturation of Xenopus oocytes; that is, progression from prophase to metaphase of meiosis. The oncogenic protein encoded by H-rasval12 is nearly a 100-fold more potent than the protein encoded by the wild-type gene. We do not observe any measurable increase or decrease in cyclic AMP concentration in injected oocytes, and the effects of H-ras protein are only partially blocked by cholera toxin. Our results suggest that not all, if any, of the effects of H-rasval12 protein in this system are mediated by adenylate cyclase.[1]

References

ras proteins can induce meiosis in Xenopus oocytes. Birchmeier, C., Broek, D., Wigler, M. Cell (1985) [Pubmed]

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