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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Prophase


High impact information on Prophase


Biological context of Prophase


Anatomical context of Prophase


Associations of Prophase with chemical compounds

  • A mutant cyclin B1 in which S133 and S147 are replaced by alanines remains in the cytoplasm, whereas wild-type cyclin B1 accumulates in the nucleus during prophase [14].
  • The cytoplasmic distribution of the antigen was also seen in nocodazole-arrested cells and prophase cells in populations treated with taxol [21].
  • Microinjection of a catalytically inactive mutant of X-PAK1 with a K/R substitution in the ATP binding site, also deleted of its Nter-half that contains the conserved domains responsible for binding of both Cdc42/Rac GTPases and SH3-containing proteins, greatly facilitates oocyte release from G2/prophase arrest by progesterone and insulin [22].
  • Prophase-accociated elongation of procentrioles appeared to occur normally in cells treated with cycloheximide for up to 4 h before prophase, though the mitotic index in treated cultures decreased somewhat [23].
  • In contrast, deletion of amino acids 19-68 or 18-61 of the NH2-terminal "head" domain produced proteins that formed extended filaments in the animal hemisphere of the prophase oocyte [24].

Gene context of Prophase


Analytical, diagnostic and therapeutic context of Prophase


  1. Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm- and Atm-p53-deficient mice. Scherthan, H., Jerratsch, M., Dhar, S., Wang, Y.A., Goff, S.P., Pandita, T.K. Mol. Cell. Biol. (2000) [Pubmed]
  2. Aberrant hypermethylation of the CHFR prophase checkpoint gene in human lung cancers. Mizuno, K., Osada, H., Konishi, H., Tatematsu, Y., Yatabe, Y., Mitsudomi, T., Fujii, Y., Takahashi, T. Oncogene (2002) [Pubmed]
  3. The mouse and human homologs of DMC1, the yeast meiosis-specific homologous recombination gene, have a common unique form of exon-skipped transcript in meiosis. Habu, T., Taki, T., West, A., Nishimune, Y., Morita, T. Nucleic Acids Res. (1996) [Pubmed]
  4. The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis. Jablonski, S.A., Chan, G.K., Cooke, C.A., Earnshaw, W.C., Yen, T.J. Chromosoma (1998) [Pubmed]
  5. Fanconi's anemia lymphocytes: effect of caffeine, adenosine and niacinamide during G2 prophase. Pincheira, J., Bravo, M., López-Sáez, J.F. Mutat. Res. (1988) [Pubmed]
  6. Mnd2, an essential antagonist of the anaphase-promoting complex during meiotic prophase. Penkner, A.M., Prinz, S., Ferscha, S., Klein, F. Cell (2005) [Pubmed]
  7. Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Ortega, S., Prieto, I., Odajima, J., Martín, A., Dubus, P., Sotillo, R., Barbero, J.L., Malumbres, M., Barbacid, M. Nat. Genet. (2003) [Pubmed]
  8. Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation. Lincoln, A.J., Wickramasinghe, D., Stein, P., Schultz, R.M., Palko, M.E., De Miguel, M.P., Tessarollo, L., Donovan, P.J. Nat. Genet. (2002) [Pubmed]
  9. An initiation site for meiotic crossing-over and gene conversion in the mouse. Guillon, H., de Massy, B. Nat. Genet. (2002) [Pubmed]
  10. A Y-encoded subunit of the translation initiation factor Eif2 is essential for mouse spermatogenesis. Mazeyrat, S., Saut, N., Grigoriev, V., Mahadevaiah, S.K., Ojarikre, O.A., Rattigan A, n.u.l.l., Bishop, C., Eicher, E.M., Mitchell, M.J., Burgoyne, P.S. Nat. Genet. (2001) [Pubmed]
  11. Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase. Waizenegger, I.C., Hauf, S., Meinke, A., Peters, J.M. Cell (2000) [Pubmed]
  12. Expression and function of Drosophila cyclin A during embryonic cell cycle progression. Lehner, C.F., O'Farrell, P.H. Cell (1989) [Pubmed]
  13. Temporal comparison of recombination and synaptonemal complex formation during meiosis in S. cerevisiae. Padmore, R., Cao, L., Kleckner, N. Cell (1991) [Pubmed]
  14. Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase. Toyoshima-Morimoto, F., Taniguchi, E., Shinya, N., Iwamatsu, A., Nishida, E. Nature (2001) [Pubmed]
  15. Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C. Takizawa, C.G., Morgan, D.O. Curr. Opin. Cell Biol. (2000) [Pubmed]
  16. Mitotic regulation of TFIID: inhibition of activator-dependent transcription and changes in subcellular localization. Segil, N., Guermah, M., Hoffmann, A., Roeder, R.G., Heintz, N. Genes Dev. (1996) [Pubmed]
  17. RAD51 and DMC1 form mixed complexes associated with mouse meiotic chromosome cores and synaptonemal complexes. Tarsounas, M., Morita, T., Pearlman, R.E., Moens, P.B. J. Cell Biol. (1999) [Pubmed]
  18. Binding of E-MAP-115 to microtubules is regulated by cell cycle-dependent phosphorylation. Masson, D., Kreis, T.E. J. Cell Biol. (1995) [Pubmed]
  19. The sudden recruitment of gamma-tubulin to the centrosome at the onset of mitosis and its dynamic exchange throughout the cell cycle, do not require microtubules. Khodjakov, A., Rieder, C.L. J. Cell Biol. (1999) [Pubmed]
  20. RAF1-activated MEK1 is found on the Golgi apparatus in late prophase and is required for Golgi complex fragmentation in mitosis. Colanzi, A., Sutterlin, C., Malhotra, V. J. Cell Biol. (2003) [Pubmed]
  21. A novel mitotic spindle pole component that originates from the cytoplasm during prophase. Sager, P.R., Rothfield, N.L., Oliver, J.M., Berlin, R.D. J. Cell Biol. (1986) [Pubmed]
  22. A member of the Ste20/PAK family of protein kinases is involved in both arrest of Xenopus oocytes at G2/prophase of the first meiotic cell cycle and in prevention of apoptosis. Faure, S., Vigneron, S., Dorée, M., Morin, N. EMBO J. (1997) [Pubmed]
  23. Dependence of centriole formation on protein synthesis. Phillips, S.G., Rattner, J.B. J. Cell Biol. (1976) [Pubmed]
  24. Host cell factors controlling vimentin organization in the Xenopus oocyte. Dent, J.A., Cary, R.B., Bachant, J.B., Domingo, A., Klymkowsky, M.W. J. Cell Biol. (1992) [Pubmed]
  25. A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiae. Cao, L., Alani, E., Kleckner, N. Cell (1990) [Pubmed]
  26. Synapsis-dependent and -independent mechanisms stabilize homolog pairing during meiotic prophase in C. elegans. MacQueen, A.J., Colaiácovo, M.P., McDonald, K., Villeneuve, A.M. Genes Dev. (2002) [Pubmed]
  27. SWITCH1 (SWI1): a novel protein required for the establishment of sister chromatid cohesion and for bivalent formation at meiosis. Mercier, R., Vezon, D., Bullier, E., Motamayor, J.C., Sellier, A., Lefèvre, F., Pelletier, G., Horlow, C. Genes Dev. (2001) [Pubmed]
  28. Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility. Wei, K., Clark, A.B., Wong, E., Kane, M.F., Mazur, D.J., Parris, T., Kolas, N.K., Russell, R., Hou, H., Kneitz, B., Yang, G., Kunkel, T.A., Kolodner, R.D., Cohen, P.E., Edelmann, W. Genes Dev. (2003) [Pubmed]
  29. Mammalian STAG3 is a cohesin specific to sister chromatid arms in meiosis I. Prieto, I., Suja, J.A., Pezzi, N., Kremer, L., Martínez-A, C., Rufas, J.S., Barbero, J.L. Nat. Cell Biol. (2001) [Pubmed]
  30. cdc25 is a nuclear protein expressed constitutively throughout the cell cycle in nontransformed mammalian cells. Girard, F., Strausfeld, U., Cavadore, J.C., Russell, P., Fernandez, A., Lamb, N.J. J. Cell Biol. (1992) [Pubmed]
  31. Down regulation of p53 with HPV E6 delays and modifies cell death in oxidant response of human diploid fibroblasts: an apoptosis-like cell death associated with mitosis. Chen, Q.M., Merrett, J.B., Dilley, T., Purdom, S. Oncogene (2002) [Pubmed]
  32. Assessment of selected co-stimulatory, adhesion and activatory molecules and cytokines of Th(1)/Th(2) balance in acute lymphoblastic leukemia in children. Luczyński, W., Stasiak-Barmuta, A., Krawczuk-Rybak, M., Malinowska, I. Arch. Immunol. Ther. Exp. (Warsz.) (2005) [Pubmed]
  33. Actinomycin D effects on termite chromosomes: induction of high resolution banding patterns with silver staining in mitotic stages. Fontana, F., Goldoni, D. Stain technology. (1986) [Pubmed]
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