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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Cornblath, D.R. et al.

Immunoreactive myelin basic protein in cerebrospinal fluid of patients with peripheral neuropathies.

The presence of myelin basic protein (MBP)-like material in cerebrospinal fluid (CSF) usually reflects breakdown of central nervous system myelin. Immunoreactive MBP levels were measured in 70 CSF specimens from 66 patients with a variety of peripheral neuropathies. Immunoreactive MBP was present in CSF in 70% (16 of 23) of patients with biopsy-proved chronic demyelinating polyneuropathies, whereas in neuropathies producing primarily axonal damage it was present in only 22% (5 of 23). In Guillain-BarrÃ© syndrome, 45% (9 of 20) of patients had immunoreactive MBP in the CSF. We conclude that MBP-like material is present in the CSF of most patients with longstanding demyelinating polyradiculoneuropathies and probably reflects detection of peripheral nervous system P1 protein.[1]

References

Immunoreactive myelin basic protein in cerebrospinal fluid of patients with peripheral neuropathies. Cornblath, D.R., Griffin, J.W., Tennekoon, G.I. Ann. Neurol. (1986) [Pubmed]

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