Gene Review:
MBP - myelin basic protein
Homo sapiens
Synonyms:
Myelin A1 protein, Myelin basic protein, Myelin membrane encephalitogenic protein
- A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor. Madsen, L.S., Andersson, E.C., Jansson, L., krogsgaard, M., Andersen, C.B., Engberg, J., Strominger, J.L., Svejgaard, A., Hjorth, J.P., Holmdahl, R., Wucherpfennig, K.W., Fugger, L. Nat. Genet. (1999)
- Distribution of papovavirus, myelin-associated glycoprotein, and myelin basic protein in progressive multifocal leukoencephalopathy lesions. Itoyama, Y., Webster, H.D., Sternberger, N.H., Richardson, E.P., Walker, D.L., Quarles, R.H., Padgett, B.L. Ann. Neurol. (1982)
- Anti-myelin basic protein and anti-proteolipid protein specific forms of multiple sclerosis. Warren, K.G., Catz, I., Johnson, E., Mielke, B. Ann. Neurol. (1994)
- Organ-specific autoantigens induce transforming growth factor-beta mRNA expression in mononuclear cells in multiple sclerosis and myasthenia gravis. Link, J., Fredrikson, S., Söderström, M., Olsson, T., Höjeberg, B., Ljungdahl, A., Link, H. Ann. Neurol. (1994)
- The involvement of specific anti myelin basic protein antibody-forming cells in multiple sclerosis immunopathology. Gerritse, K., Deen, C., Fasbender, M., Ravid, R., Boersma, W., Claassen, E. J. Neuroimmunol. (1994)
- Intrathecal synthesis of anti-myelin basic protein IgG in HIV-1+ patients. Maimone, D., Annunziata, P., Cioni, C., Leonardi, A., Guazzi, G.C. Acta neurologica Scandinavica. (1994)
- Cross-reactive idiotypy in cerebrospinal fluid immunoglobulins in multiple sclerosis. LaGanke, C.C., Freeman, D.W., Whitaker, J.N. Ann. Neurol. (2000)
- Myelin basic protein antibodies in catatonic schizophrenia. Rimón, R., Ahokas, A., Ruutiainen, J., Halonen, P. The Journal of clinical psychiatry. (1986)
- Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Wucherpfennig, K.W., Strominger, J.L. Cell (1995)
- Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases. Thomas, S.M., DeMarco, M., D'Arcangelo, G., Halegoua, S., Brugge, J.S. Cell (1992)
- Myelin basic protein as an encephalitogen in encephalomyelitis and polyneuritis following rabies vaccination. Hemachudha, T., Griffin, D.E., Giffels, J.J., Johnson, R.T., Moser, A.B., Phanuphak, P. N. Engl. J. Med. (1987)
- Interleukin-1 activates p54 mitogen-activated protein (MAP) kinase/stress-activated protein kinase by a pathway that is independent of p21ras, Raf-1, and MAP kinase kinase. Bird, T.A., Kyriakis, J.M., Tyshler, L., Gayle, M., Milne, A., Virca, G.D. J. Biol. Chem. (1994)
- Cryoelectron microscopy of protein-lipid complexes of human myelin basic protein charge isomers differing in degree of citrullination. Beniac, D.R., Wood, D.D., Palaniyar, N., Ottensmeyer, F.P., Moscarello, M.A., Harauz, G. J. Struct. Biol. (2000)
- Longitudinal study of myelin basic protein-specific T-cell receptors during the course of multiple sclerosis. Lovett-Racke, A.E., Martin, R., McFarland, H.F., Racke, M.K., Utz, U. J. Neuroimmunol. (1997)
- Enhanced T cell responsiveness to citrulline-containing myelin basic protein in multiple sclerosis patients. Tranquill, L.R., Cao, L., Ling, N.C., Kalbacher, H., Martin, R.M., Whitaker, J.N. Mult. Scler. (2000)
- Antibodies against the myelin oligodendrocyte glycoprotein and the myelin basic protein in multiple sclerosis and other neurological diseases: a comparative study. Reindl, M., Linington, C., Brehm, U., Egg, R., Dilitz, E., Deisenhammer, F., Poewe, W., Berger, T. Brain (1999)
- Two different signal transduction pathways can be activated by transforming growth factor beta 1 in epithelial cells. Yan, Z., Winawer, S., Friedman, E. J. Biol. Chem. (1994)
- Conjugal multiple sclerosis: immunogenetic characterization and analysis of T- and B-cell reactivity to myelin proteins. Fredrikson, S., Michelsberg, J., Hillert, J., Wang, Z., Sun, J.B., Olerup, O., Olsson, T., Link, H. Neurology (1992)
- Effect of phosphorylation of myelin basic protein by MAPK on its interactions with actin and actin binding to a lipid membrane in vitro. Boggs, J.M., Rangaraj, G., Gao, W., Heng, Y.M. Biochemistry (2006)
- Predominant and stable T cell responses to regions of myelin basic protein can be detected in individual patients with multiple sclerosis. Salvetti, M., Ristori, G., D'Amato, M., Buttinelli, C., Falcone, M., Fieschi, C., Wekerle, H., Pozzilli, C. Eur. J. Immunol. (1993)
- Myelin basic protein-specific T-cell responses in identical twins discordant or concordant for multiple sclerosis. Martin, R., Voskuhl, R., Flerlage, M., McFarlin, D.E., McFarland, H.F. Ann. Neurol. (1993)
- Immunohistochemical detection of myelin basic protein is a sensitive marker of myelination in second trimester human fetal spinal cord. Bodhireddy, S.R., Lyman, W.D., Rashbaum, W.K., Weidenheim, K.M. J. Neuropathol. Exp. Neurol. (1994)
- The T-lymphocyte response against myelin-associated glycoprotein and myelin basic protein in patients with multiple sclerosis. Zhang, Y., Burger, D., Saruhan, G., Jeannet, M., Steck, A.J. Neurology (1993)
- Differential activation of c-Jun NH2-terminal kinase and p38 pathways during FTY720-induced apoptosis of T lymphocytes that is suppressed by the extracellular signal-regulated kinase pathway. Matsuda, S., Minowa, A., Suzuki, S., Koyasu, S. J. Immunol. (1999)
- Demyelinating antibodies to myelin oligodendrocyte glycoprotein and galactocerebroside induce degradation of myelin basic protein in isolated human myelin. Menon, K.K., Piddlesden, S.J., Bernard, C.C. J. Neurochem. (1997)
- Characterization of fertilization-modulated myelin basic protein kinases from sea star: regulation of Mapk. Lefebvre, D.L., Charest, D.L., Yee, A., Crawford, B.J., Pelech, S.L. J. Cell. Biochem. (1999)
- Structural insight into the function of myelin basic protein as a ligand for integrin alpha M beta 2. Stapulionis, R., Oliveira, C.L., Gjelstrup, M.C., Pedersen, J.S., Hokland, M.E., Hoffmann, S.V., Poulsen, K., Jacobsen, C., Vorup-Jensen, T. J. Immunol. (2008)
- Linear epitopes of two different autoantigens-La/SSB and myelin basic protein--with a high degree of molecular similarity, cause different humoral immune responses. Terzoglou, A.G., Routsias, J.G., Sakarellos, C., Sakarellos-Daitsiotis, M., Moutsopoulos, H.M., Tzioufas, A.G. J. Autoimmun. (2003)
- Catalytic reaction pathway for the mitogen-activated protein kinase ERK2. Prowse, C.N., Hagopian, J.C., Cobb, M.H., Ahn, N.G., Lew, J. Biochemistry (2000)
- Marburg's variant of multiple sclerosis correlates with a less compact structure of myelin basic protein. Beniac, D.R., Wood, D.D., Palaniyar, N., Ottensmeyer, F.P., Moscarello, M.A., Harauz, G. Mol. Cell Biol. Res. Commun. (1999)
- Inhibition of Familial Cerebral Amyloid Angiopathy Mutant Amyloid beta-Protein Fibril Assembly by Myelin Basic Protein. Hoos, M.D., Ahmed, M., Smith, S.O., Van Nostrand, W.E. J. Biol. Chem. (2007)
- MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway. Lin, J.L., Chen, H.C., Fang, H.I., Robinson, D., Kung, H.J., Shih, H.M. Oncogene (2001)
- PRMT5 (Janus kinase-binding protein 1) catalyzes the formation of symmetric dimethylarginine residues in proteins. Branscombe, T.L., Frankel, A., Lee, J.H., Cook, J.R., Yang , Z., Pestka, S., Clarke, S. J. Biol. Chem. (2001)
- LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes. Kuramochi, S., Moriguchi, T., Kuida, K., Endo, J., Semba, K., Nishida, E., Karasuyama, H. J. Biol. Chem. (1997)
- Phosphatidylinositol 3-kinase-dependent activation of protein kinase C-zeta in bacterial lipopolysaccharide-treated human monocytes. Herrera-Velit, P., Knutson, K.L., Reiner, N.E. J. Biol. Chem. (1997)
- Metal-dependent hydrolysis of myelin basic protein by IgGs from the sera of patients with multiple sclerosis. Polosukhina, D.I., Kanyshkova, T.G., Doronin, B.M., Tyshkevich, O.B., Buneva, V.N., Boiko, A.N., Gusev, E.I., Nevinsky, G.A., Favorova, O.O. Immunol. Lett. (2006)
- Low density lipoprotein uptake by macrophages in multiple sclerosis plaques: implications for pathogenesis. Newcombe, J., Li, H., Cuzner, M.L. Neuropathol. Appl. Neurobiol. (1994)
- Interleukin-4 and RANTES expression in maturing eosinophils derived from human cord blood CD34+ progenitors. Velazquez, J.R., Lacy, P., Mahmudi-Azer, S., Bablitz, B., Milne, C.D., Denburg, J.A., Moqbel, R. Immunology (2000)
- Temporal and spatial expression of major myelin proteins in the human fetal spinal cord during the second trimester. Weidenheim, K.M., Bodhireddy, S.R., Rashbaum, W.K., Lyman, W.D. J. Neuropathol. Exp. Neurol. (1996)
- Human anti-idiotypic T cells induced by TCR peptides corresponding to a common CDR3 sequence motif in myelin basic protein-reactive T cells. Zang, Y.C., Hong, J., Rivera, V.M., Killian, J., Zhang, J.Z. Int. Immunol. (2003)
- Myelin basic protein gene is associated with MS in DR4- and DR5-positive Italians and Russians. Guerini, F.R., Ferrante, P., Losciale, L., Caputo, D., Lombardi, M.L., Pirozzi, G., Luongo, V., Sudomoina, M.A., Andreewski, T.V., Alekseenkov, A.D., Boiko, A.N., Gusev, E.I., Favorova, O.O. Neurology (2003)
- Autoreactive CD8+ T-cell responses to human myelin protein-derived peptides. Tsuchida, T., Parker, K.C., Turner, R.V., McFarland, H.F., Coligan, J.E., Biddison, W.E. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Cytokine profile of myelin basic protein-reactive T cells in multiple sclerosis and healthy individuals. Hermans, G., Stinissen, P., Hauben, L., Van den Berg-Loonen, E., Raus, J., Zhang, J. Ann. Neurol. (1997)
- Prmt5, which forms distinct homo-oligomers, is a member of the protein-arginine methyltransferase family. Rho, J., Choi, S., Seong, Y.R., Cho, W.K., Kim, S.H., Im, D.S. J. Biol. Chem. (2001)
- Differential macrophage/microglia activation in neocortical EAE lesions in the marmoset monkey. Merkler, D., Böscke, R., Schmelting, B., Czéh, B., Fuchs, E., Brück, W., Stadelmann, C. Brain Pathol. (2006)
- A role for CXCL12 (SDF-1alpha) in the pathogenesis of multiple sclerosis: regulation of CXCL12 expression in astrocytes by soluble myelin basic protein. Calderon, T.M., Eugenin, E.A., Lopez, L., Kumar, S.S., Hesselgesser, J., Raine, C.S., Berman, J.W. J. Neuroimmunol. (2006)