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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Production and auto-induction of transforming growth factor-alpha in human keratinocytes.

Transforming growth factor-alpha (TGF-alpha) is a polypeptide which is structurally related to epidermal growth factor (EGF) and binds to the EGF receptor. TGF-alpha synthesis occurs in a variety of neoplastic cells and during early fetal development but has not been reported in normal cells of the adult organisms. TGF-alpha has therefore been regarded as an embryonic growth factor which is inappropriately expressed during neoplasia. Here we report that primary cultures of normal human keratinocytes synthesize TGF-alpha. Furthermore, we show that addition of EGF or TGF-alpha to these cultures induces TGF-alpha gene expression, suggesting that a mechanism of auto-induction exists. Analysis of normal skin biopsies using in situ hybridization and immunohistochemistry demonstrates the in vivo presence of TGF-alpha messenger RNA and protein in the stratified epidermis.[1]


  1. Production and auto-induction of transforming growth factor-alpha in human keratinocytes. Coffey, R.J., Derynck, R., Wilcox, J.N., Bringman, T.S., Goustin, A.S., Moses, H.L., Pittelkow, M.R. Nature (1987) [Pubmed]
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