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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Interferon-gamma activates the voltage-gated calcium channel in RPMI 4788 cells.

Interferon (IFN) increases cytoplasmic free calcium ([Ca2+]i) in RPMI 4788 cells, a human colon cancer cell line. Addition of IFN to the cells loaded with Fura-2, a fluorescent Ca2+ indicator, causes an immediate increase in [Ca2+]i, which is the earliest event after IFN stimulation. A cyanine dye, dis-C3- (5) was used to determine the effects of IFN on the membrane potential in cancer cells. The depolarization was seen with IFN-gamma, but not with IFN-beta. These results taken together, suggest that the IFN-gamma and -beta induced [Ca2+]i mobilization are clearly different in their dependence on Ca2+ entry through voltage-gated Ca2+ channels.[1]

References

  1. Interferon-gamma activates the voltage-gated calcium channel in RPMI 4788 cells. Iwagaki, H., Fuchimoto, S., Miyake, M., Aoki, H., Orita, K. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
 
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