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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Capreomycin kinetics in renal impairment and clearance by hemodialysis.

The single-dose kinetics of capreomycin are described for 12 renal patients and seven healthy control subjects. Creatinine clearances (CrCl) ranged from zero to 121 ml/min. After single-dose intravenous infusions, mean +/- SD capreomycin clearance values (L/kg/h x 10(-2)) were 0.558 +/- 0.160 for the dialysis group (n = 4, CrCl = 1.4 +/- 1.9), 1.77 +/- 0.45 for the moderate renal group (n = 3, CrCl = 25 +/- 5), 2.82 +/- 1.52 for the mild renal group (n = 4, CrCl = 46 +/- 5), and 5.73 +/- 1.54 for the normal renal group (n = 7, CrCl = 109 +/- 11); p less than 0.01, using analysis of variance. The correlation between capreomycin clearance and CrCl was r = 0.90. Hemodialysis cleared clinically significant amounts of capreomycin. These data imply that capreomycin maintenance doses need to be reduced for renal patients.[1]

References

  1. Capreomycin kinetics in renal impairment and clearance by hemodialysis. Lehmann, C.R., Garrett, L.E., Winn, R.E., Springberg, P.D., Vicks, S., Porter, D.K., Pierson, W.P., Wolny, J.D., Brier, G.L., Black, H.R. Am. Rev. Respir. Dis. (1988) [Pubmed]
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