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Chemical Compound Review

Capastat     (3S)-3,6-diamino-N- [[(2S,5S,8E,11S,15S)-15...

Synonyms: Ogostal, AC1MHD7F, DB00314, Ogostal (Disulfate), Capreomycin sulphate, ...
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Disease relevance of Capastat


High impact information on Capastat


Chemical compound and disease context of Capastat


Biological context of Capastat


Associations of Capastat with other chemical compounds


Gene context of Capastat

  • Marked renal potassium and magnesium wasting, alkalosis, and a progressive increase in plasma renin and eventual hyperaldosteronemia developed during a 15-month course of in-hospital capreomycin therapy that was necessary for drug-resistant pulmonary tuberculosis [14].

Analytical, diagnostic and therapeutic context of Capastat


  1. Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs. Johansen, S.K., Maus, C.E., Plikaytis, B.B., Douthwaite, S. Mol. Cell (2006) [Pubmed]
  2. Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis. Maus, C.E., Plikaytis, B.B., Shinnick, T.M. Antimicrob. Agents Chemother. (2005) [Pubmed]
  3. Pharmacokinetics, toxicity, and efficacy of liposomal capreomycin in disseminated Mycobacterium avium beige mouse model. Le Conte, P., Le Gallou, F., Potel, G., Struillou, L., Baron, D., Drugeon, H.B. Antimicrob. Agents Chemother. (1994) [Pubmed]
  4. Molecular analysis of cross-resistance to capreomycin, kanamycin, amikacin, and viomycin in Mycobacterium tuberculosis. Maus, C.E., Plikaytis, B.B., Shinnick, T.M. Antimicrob. Agents Chemother. (2005) [Pubmed]
  5. Resazurin microtiter assay plate testing of Mycobacterium tuberculosis susceptibilities to second-line drugs: rapid, simple, and inexpensive method. Martin, A., Camacho, M., Portaels, F., Palomino, J.C. Antimicrob. Agents Chemother. (2003) [Pubmed]
  6. In-vitro activities of aminoglycoside-aminocyclitols against mycobacteria. Ho, Y.I., Chan, C.Y., Cheng, A.F. J. Antimicrob. Chemother. (1997) [Pubmed]
  7. Sensitivity to capreomycin and prothionamide in strains of Mycobacterium, Nocardia, Rhodococcus, and related taxa for taxonomical purposes. Ridell, M. Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectiousdiseases, para... (1983) [Pubmed]
  8. Multidrug-resistant tuberculosis in pregnancy: case report and review of the literature. Lessnau, K.D., Qarah, S. Chest (2003) [Pubmed]
  9. Resistance of multidrug-resistant strains of Mycobacterium tuberculosis from the Archangel oblast, Russia, to second-line anti-tuberculosis drugs. Toungoussova, O.S., Mariandyshev, A.O., Bjune, G., Caugant, D.A., Sandven, P. Eur. J. Clin. Microbiol. Infect. Dis. (2005) [Pubmed]
  10. Capreomycin kinetics in renal impairment and clearance by hemodialysis. Lehmann, C.R., Garrett, L.E., Winn, R.E., Springberg, P.D., Vicks, S., Porter, D.K., Pierson, W.P., Wolny, J.D., Brier, G.L., Black, H.R. Am. Rev. Respir. Dis. (1988) [Pubmed]
  11. The chemical structure of capreomycin. Shiba, T., Nomoto, S., Wakamiya, T. Experientia (1976) [Pubmed]
  12. Characterization of Mycobacterium tuberculosis complex isolates from the cerebrospinal fluid of meningitis patients at six fever hospitals in Egypt. Cooksey, R.C., Abbadi, S.H., Woodley, C.L., Sikes, D., Wasfy, M., Crawford, J.T., Mahoney, F. J. Clin. Microbiol. (2002) [Pubmed]
  13. A reproducible, simple, and sensitive high-performance capillary electrophoresis method for simultaneous determination of capreomycin, ofloxacin and pasiniazide in urine. Zhang, S.S., Liu, H.X., Yuan, Z.B., Yu, C.L. Journal of pharmaceutical and biomedical analysis. (1998) [Pubmed]
  14. A Bartter's-like syndrome from capreomycin, and a similar gentamicin tubulopathy. Steiner, R.W., Omachi, A.S. Am. J. Kidney Dis. (1986) [Pubmed]
  15. Treatment and prevention of multidrug-resistant tuberculosis. Bastian, I., Colebunders, R. Drugs (1999) [Pubmed]
  16. UV spectroscopy and reverse-phase HPLC as novel methods to determine Capreomycin of liposomal fomulations. Rossi, C., Fardella, G., Chiappini, I., Perioli, L., Vescovi, C., Ricci, M., Giovagnoli, S., Scuota, S. Journal of pharmaceutical and biomedical analysis. (2004) [Pubmed]
  17. Capreomycin is active against non-replicating M. tuberculosis. Heifets, L., Simon, J., Pham, V. Ann. Clin. Microbiol. Antimicrob. (2005) [Pubmed]
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