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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Demonstration of receptors for parathyroid hormone on cultured rabbit costal chondrocytes.

Parathyroid hormone ( PTH) receptors on cultured rabbit costal chondrocytes were demonstrated using HPLC-purified, radioiodinated [Nle8,-Nle18, Tyr34] bovine PTH-(1-34)amide. PTH binding was found to be specific for PTH agonists and antagonists and dependent on the time and temperature of incubation. Both growth cartilage ( GC) cells and resting cartilage (RC) cells were shown to have a single class of saturable, high affinity PTH binding sites with a dissociation constant of 0.6-0.7 nM. However, the numbers of receptors per cell were approximately 49,000 on GC cells and 19,000 on RC cells. After crosslinking the receptors on these cells with the radioligand, one, major 125I-labeled band of 76 kDa was separated by SDS-PAGE.[1]

References

  1. Demonstration of receptors for parathyroid hormone on cultured rabbit costal chondrocytes. Enomoto, M., Kinoshita, A., Pan, H.O., Suzuki, F., Yamamoto, I., Takigawa, M. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
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