The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Effect of in vivo lithium treatment on (-)isoproterenol-stimulated cAMP accumulation in lymphocytes of healthy subjects and patients with affective psychoses.

Lithium treatment inhibited (-)isoproterenol-stimulated cAMP accumulation in lymphocytes of 83% of the normal control subjects investigated. Of the normal control subjects, 17% did not show inhibition of cAMP synthesis after lithium treatment. In one single normal control subject a clear inverse correlation was found between lithium serum concentration and maximal cAMP response. The cAMP levels of six manic-depressive and of four schizoaffective patients receiving lithium treatment did not differ significantly from those of 10 lithium-treated normal subjects. The results obtained in normal subjects seem to support the hypothesis that lithium reduces postsynaptic receptor sensitivity by decreasing cAMP response to agonist stimulation. Treatment outcome, however, does not seem to be exclusively related to a blunted noradrenergic response, since the only patient who did not respond to the treatment had a very low (-)isoproterenol-induced cAMP response after lithium treatment.[1]


WikiGenes - Universities