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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Topical salicylate therapy (4-ASA and 5-ASA enemas).

Topical therapy with amino salicylate enemas is the treatment of choice for proctitis, proctosigmoiditis, and left-sided ulcerative colitis. Adjunctive sulfasalazine therapy is often required. Relapse rates of 80 per cent can be expected within 3 months of discontinuing therapy.[1]


  1. Topical salicylate therapy (4-ASA and 5-ASA enemas). Ginsberg, A.L. Gastroenterol. Clin. North Am. (1989) [Pubmed]
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