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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Is there a third heart beta-adrenoceptor?

A series of partial agonists with high affinity for myocardial beta 1- and beta 2-adrenoceptors cause stimulant effects in heart that are resistant to blockade of beta 1- and beta 2-adrenoceptors. The concentrations of partial agonist that cause stimulant effects greatly exceed those that cause blockade. Alberto Kaumann suggests that such non-conventional partial agonists, often analogues of pindolol, may act through a third heart beta-adrenoceptor, which resembles the beta 3-adrenoceptor of white adipocytes and smooth muscle of airways and ileum.[1]


  1. Is there a third heart beta-adrenoceptor? Kaumann, A.J. Trends Pharmacol. Sci. (1989) [Pubmed]
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