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Gene Review

ADRB3  -  adrenoceptor beta 3

Homo sapiens

Synonyms: ADRB3R, B3AR, Beta-3 adrenergic receptor, Beta-3 adrenoceptor, Beta-3 adrenoreceptor
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Disease relevance of ADRB3

  • These findings do not support the view that there is an association between the Trp64Arg mutation in the ADRB3 gene and obesity [1].
  • We conclude that the Trp(64)Arg mutation of ADRB3 has little or no influence on either body weight or body mass index in the general Japanese population [2].
  • Stimulation of the ADRB3 adrenergic receptor induces relaxation of human placental arteries: influence of preeclampsia [3].
  • The Trp64Arg polymorphism of beta(3)-adrenergic receptor (ADRB3) has been reported to be associated with insulin resistance and gestational diabetes mellitus (GDM) [4].
  • CONCLUSION: A potential association may exist between risk of breast cancer and polymorphisms in the ADRB2 and ADRB3 genes; further studies in larger samples and/or in different ethnic groups are warranted to investigate this potential association [5].

Psychiatry related information on ADRB3


High impact information on ADRB3


Chemical compound and disease context of ADRB3


Biological context of ADRB3


Anatomical context of ADRB3


Associations of ADRB3 with chemical compounds


Physical interactions of ADRB3


Regulatory relationships of ADRB3


Other interactions of ADRB3

  • Association analysis of the entire group showed significant evidence for a synergistic effect between the Thr92Ala DIO2 and Trp64Arg ADRB3 variants on BMI (both variants 34.3 plus minus 0.9 kg/m(2) vs. neither variant 33.1 plus minus 0.4 kg/m(2), P = 0.04 for interaction) [30].
  • RT-PCR was performed on RNA obtained from 23 different human tissues, using primers for the beta 3AR, the beta 2AR, and beta-actin, which acted as a control [17].
  • Moreover, in women, a statistically significant interaction (P=0.026) between the LPL and the ADRB3 gene loci in determining BMI was found [31].
  • No statistically significant relationship was demonstrated for the investigated ADRB3 Trp64Arg and the GNB3 C825T polymorphisms in terms of BWC post-treatment, suggesting these two polymorphisms do not play a significant role in clozapine-induced BWC [32].
  • Three SNPs (803T>C of AGT, 677CT of MTHFR, 190T>C of ADRB3) showed weak differences in allelic frequency [33].

Analytical, diagnostic and therapeutic context of ADRB3


  1. The Trp64Arg mutation of the beta3 adrenergic receptor gene has no effect on obesity phenotypes in the Québec Family Study and Swedish Obese Subjects cohorts. Gagnon, J., Mauriège, P., Roy, S., Sjöström, D., Chagnon, Y.C., Dionne, F.T., Oppert, J.M., Pérusse, L., Sjöström, L., Bouchard, C. J. Clin. Invest. (1996) [Pubmed]
  2. The Trp(64)Arg polymorphism of the beta(3)-adrenergic receptor gene is not associated with body weight or body mass index in Japanese: a longitudinal analysis. Matsushita, Y., Yokoyama, T., Yoshiike, N., Matsumura, Y., Date, C., Kawahara, K., Tanaka, H. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  3. Stimulation of the ADRB3 adrenergic receptor induces relaxation of human placental arteries: influence of preeclampsia. Rouget, C., Barthez, O., Goirand, F., Leroy, M.J., Breuiller-Fouché, M., Rakotoniaina, Z., Guérard, P., Morcillo, E.J., Advenier, C., Sagot, P., Cabrol, D., Dumas, M., Bardou, M. Biol. Reprod. (2006) [Pubmed]
  4. Lack of relationship between beta3-adrenergic receptor gene polymorphism and gestational diabetes mellitus in a Taiwanese population. Tsai, P.J., Ho, S.C., Tsai, L.P., Lee, Y.H., Hsu, S.P., Yang, S.P., Chu, C.H., Yu, C.H. Metab. Clin. Exp. (2004) [Pubmed]
  5. Possible association of beta2- and beta3-adrenergic receptor gene polymorphisms with susceptibility to breast cancer. Huang, X.E., Hamajima, N., Saito, T., Matsuo, K., Mizutani, M., Iwata, H., Iwase, T., Miura, S., Mizuno, T., Tokudome, S., Tajima, K. Breast Cancer Res. (2001) [Pubmed]
  6. Beta 3-adrenergic-receptor allele distributions in children, adolescents and young adults with obesity, underweight or anorexia nervosa. Hinney, A., Lentes, K.U., Rosenkranz, K., Barth, N., Roth, H., Ziegler, A., Hennighausen, K., Coners, H., Wurmser, H., Jacob, K., Römer, G., Winnikes, U., Mayer, H., Herzog, W., Lehmkuhl, G., Poustka, F., Schmidt, M.H., Blum, W.F., Pirke, K.M., Schäfer, H., Grzeschik, K.H., Remschmidt, H., Hebebrand, J. Int. J. Obes. Relat. Metab. Disord. (1997) [Pubmed]
  7. Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. Clément, K., Vaisse, C., Manning, B.S., Basdevant, A., Guy-Grand, B., Ruiz, J., Silver, K.D., Shuldiner, A.R., Froguel, P., Strosberg, A.D. N. Engl. J. Med. (1995) [Pubmed]
  8. Association of a polymorphism in the beta 3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns. Widén, E., Lehto, M., Kanninen, T., Walston, J., Shuldiner, A.R., Groop, L.C. N. Engl. J. Med. (1995) [Pubmed]
  9. beta3-adrenoceptor control the cystic fibrosis transmembrane conductance regulator through a cAMP/protein kinase A-independent pathway. Leblais, V., Demolombe, S., Vallette, G., Langin, D., Baró, I., Escande, D., Gauthier, C. J. Biol. Chem. (1999) [Pubmed]
  10. Association of Trp64Arg mutation of the beta3-adrenergic-receptor with NIDDM and body weight gain. Fujisawa, T., Ikegami, H., Yamato, E., Takekawa, K., Nakagawa, Y., Hamada, Y., Oga, T., Ueda, H., Shintani, M., Fukuda, M., Ogihara, T. Diabetologia (1996) [Pubmed]
  11. Development of infrared imaging to measure thermogenesis in cell culture: thermogenic effects of uncoupling protein-2, troglitazone, and beta-adrenoceptor agonists. Paulik, M.A., Buckholz, R.G., Lancaster, M.E., Dallas, W.S., Hull-Ryde, E.A., Weiel, J.E., Lenhard, J.M. Pharm. Res. (1998) [Pubmed]
  12. Tremor and the anti-obesity drug BRL 26830A. Connacher, A.A., Lakie, M., Powers, N., Elton, R.A., Walsh, E.G., Jung, R.T. British journal of clinical pharmacology. (1990) [Pubmed]
  13. Different regulation of free fatty acid levels and glucose oxidation by the Trp64Arg polymorphism of the beta3-adrenergic receptor gene and the promoter variant (A-3826G) of the uncoupling protein 1 gene in familial combined hyperlipidemia. Pihlajamäki, J., Rissanen, J., Valve, R., Heikkinen, S., Karjalainen, L., Laakso, M. Metab. Clin. Exp. (1998) [Pubmed]
  14. Molecular analysis of adrenergic receptor genes and interleukin-4/interleukin-4 receptor genes in patients with interstitial cystitis. Sugaya, K., Nishijima, S., Yamada, T., Miyazato, M., Hatano, T., Ogawa, Y. J. Urol. (2002) [Pubmed]
  15. beta(3) Adrenergic receptor polymorphism and obesity-related phenotypes in hypertensive patients. Hao, K., Peng, S., Xing, H., Yu, Y., Huang, A., Hong, X., Wang, Y., Chen, C., Wang, B., Zhang, X., Liu, J., Zhu, G., Huo, Y., Chen, D., Zhao, X., Ronnenberg, A., Wu, D., Niu, T., Xu, X. Obes. Res. (2004) [Pubmed]
  16. Characterization of the region of the short arm of chromosome 8 amplified in breast carcinoma. Dib, A., Adélaïde, J., Chaffanet, M., Imbert, A., Le Paslier, D., Jacquemier, J., Gaudray, P., Theillet, C., Birnbaum, D., Pébusque, M.J. Oncogene (1995) [Pubmed]
  17. Lack of beta 3-adrenergic receptor mRNA expression in adipose and other metabolic tissues in the adult human. Thomas, R.F., Liggett, S.B. Mol. Pharmacol. (1993) [Pubmed]
  18. Evidence for a functional beta 3-adrenoceptor in man. Lönnqvist, F., Krief, S., Strosberg, A.D., Nyberg, S., Emorine, L.J., Arner, P. Br. J. Pharmacol. (1993) [Pubmed]
  19. Beta-adrenoceptor-mediated inhibition of mediator release from human peripheral blood-derived mast cells. Wang, X.S., Lau, H.Y. Clin. Exp. Pharmacol. Physiol. (2006) [Pubmed]
  20. No evidence for an association between genetic polymorphisms of beta(2)- and beta(3)-adrenergic receptor genes with body mass index in Aymara natives from Chile. Santos, J.L., Pérez-Bravo, F., Martínez, J.A., Montalvo, D., Albala, C., Carrasco, E. Nutrition (Burbank, Los Angeles County, Calif.) (2002) [Pubmed]
  21. A pathogenic role of visceral fat beta 3-adrenoceptors in obesity. Lönnqvist, F., Thöme, A., Nilsell, K., Hoffstedt, J., Arner, P. J. Clin. Invest. (1995) [Pubmed]
  22. Lack of beta 3-adrenergic effect on lipolysis in human subcutaneous adipose tissue. Rosenbaum, M., Malbon, C.C., Hirsch, J., Leibel, R.L. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  23. Beta 3-adrenoceptor agonists, BRL 37344 and SR 58611A, do not induce relaxation of human, sheep and guinea-pig airway smooth muscle in vitro. Martin, C.A., Naline, E., Bakdach, H., Advenier, C. Eur. Respir. J. (1994) [Pubmed]
  24. beta3-Adrenergic receptor Trp64Arg polymorphism and increased body mass index in sleep apnoea. Piérola, J., Barceló, A., de la Peña, M., Barbé, F., Soriano, J.B., Sánchez Armengol, A., Martínez, C., Agustí, A. Eur. Respir. J. (2007) [Pubmed]
  25. beta3-adrenergic receptor activation increases human atrial tissue contractility and stimulates the L-type Ca2+ current. Skeberdis, V.A., Gendviliene, V., Zablockaite, D., Treinys, R., Macianskiene, R., Bogdelis, A., Jurevicius, J., Fischmeister, R. J. Clin. Invest. (2008) [Pubmed]
  26. Determination of structural domains for G protein coupling and ligand binding in beta 3-adrenergic receptor. Guan, X.M., Amend, A., Strader, C.D. Mol. Pharmacol. (1995) [Pubmed]
  27. Effect of Trp64Arg mutation of the beta3-adrenergic receptor gene and C161T substitution of the peroxisome proliferator activated receptor gamma gene on obesity in Japanese children. Arashiro, R., Katsuren, K., Fukuyama, S., Ohta, T. Pediatrics international : official journal of the Japan Pediatric Society. (2003) [Pubmed]
  28. Effects of selective beta2 and beta3-adrenoceptor agonists on detrusor hyperreflexia in conscious cerebral infarcted rats. Kaidoh, K., Igawa, Y., Takeda, H., Yamazaki, Y., Akahane, S., Miyata, H., Ajisawa, Y., Nishizawa, O., Andersson, K.E. J. Urol. (2002) [Pubmed]
  29. Mechanisms of beta 3-adrenoceptor-induced eNOS activation in right atrial and left ventricular human myocardium. Brixius, K., Bloch, W., Pott, C., Napp, A., Krahwinkel, A., Ziskoven, C., Koriller, M., Mehlhorn, U., Hescheler, J., Fleischmann, B., Schwinger, R.H. Br. J. Pharmacol. (2004) [Pubmed]
  30. Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: evidence of interaction with the Trp64Arg variant of the beta-3-adrenergic receptor. Mentuccia, D., Proietti-Pannunzi, L., Tanner, K., Bacci, V., Pollin, T.I., Poehlman, E.T., Shuldiner, A.R., Celi, F.S. Diabetes (2002) [Pubmed]
  31. Gender specific associations of the Trp64Arg mutation in the beta3-adrenergic receptor gene with obesity-related phenotypes in a Mediterranean population: interaction with a common lipoprotein lipase gene variation. Corella, D., Guillén, M., Portolés, O., Sorlí, J.V., Alonso, V., Folch, J., Sáiz, C. J. Intern. Med. (2001) [Pubmed]
  32. Association study of adrenergic beta3 receptor (Trp64Arg) and G-protein beta3 subunit gene (C825T) polymorphisms and weight change during clozapine treatment. Tsai, S.J., Yu, Y.W., Lin, C.H., Wang, Y.C., Chen, J.Y., Hong, C.J. Neuropsychobiology (2004) [Pubmed]
  33. Highly multiplexed genotyping of coronary artery disease-associated SNPs using MALDI-TOF mass spectrometry. Nakai, K., Habano, W., Fujita, T., Nakai, K., Schnackenberg, J., Kawazoe, K., Suwabe, A., Itoh, C. Hum. Mutat. (2002) [Pubmed]
  34. Prospects for beta 3-adrenoceptor agonists in the treatment of obesity and diabetes. Arch, J.R., Wilson, S. Int. J. Obes. Relat. Metab. Disord. (1996) [Pubmed]
  35. A study on the genetics of obesity: influence of polymorphisms of the beta-3-adrenergic receptor and insulin receptor substrate 1 in relation to weight loss, waist to hip ratio and frequencies of common cardiovascular risk factors. Benecke, H., Topak, H., von zur Mühlen, A., Schuppert, F. Exp. Clin. Endocrinol. Diabetes (2000) [Pubmed]
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