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Major acute-phase alpha(1)protein in the rat: structure, molecular cloning, and regulation of mRNA levels.

Rat major acute-phase alpha(1)protein (MAP) was characterized by determining its secondary structure, ligand binding and partial amino acid sequence. A cDNA clone expressing MAP and coding for the entire mature protein was isolated from a cDNA library in E. coli prepared from rat liver mRNA. By hybridization to nick translated cDNA, mRNA for MAP was found only in liver, where it increased 17-fold during acute inflammation. Constant proportions of rates of leucine incorporation into MAP over mRNA levels in liver indicated that the regulation of the synthesis of MAP is due to a change in the rate of synthesis and/or the stability of mRNA for MAP, but not the rate of its translation.[1]

References

  1. Major acute-phase alpha(1)protein in the rat: structure, molecular cloning, and regulation of mRNA levels. Cole, T., Inglis, A., Nagashima, M., Schreiber, G. Biochem. Biophys. Res. Commun. (1985) [Pubmed]
 
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