The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Kng1l1  -  kininogen 1-like 1

Rattus norvegicus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of MGC108747

  • Regardless of whether inflammation was induced by surgical injury or by a subcutaneous turpentine injection, within 48 h the serum concentration of this major acute-phase protein rose from the normal value of 0.46 g/liter to a maximum value of 7.2 g/liter, which constituted 10% of the total serum protein [1].
  • The major acute phase protein AG level is increased in BBD rats already on the first day of appearance of glycosuria [2].
  • In adrenalectomized male rats the increase of plasma alpha 1-MAP concentration was not different from that observed in sham-operated rats, suggesting that the acute phase response of this protein is not corticoid dependent [3].

High impact information on MGC108747


Biological context of MGC108747


Anatomical context of MGC108747

  • Translation of rough microsomes yields a product with a mass of 57,000 Da, representing the core glycosylated form of alpha 1-MAP [12].
  • Cotranslational glycosylation appears to occur in a stepwise fashion, since three glycosylated forms of alpha 1-MAP (51,000, 54,000, and 57,000 Da) were detected in polysome translations; these products were digested by endoglycosidase H to a 48,000-Da protein [12].
  • Using in vitro and in vivo systems, various biosynthetic processing intermediates of this glycoprotein have been isolated. alpha 1-MAP is translated in a rabbit reticulocyte system as a preprotein with an amino-terminal signal peptide and an apparent molecular weight of 51,000 [12].

Associations of MGC108747 with chemical compounds


Other interactions of MGC108747


Analytical, diagnostic and therapeutic context of MGC108747


  1. A rat serum glycoprotein whose synthesis rate increases greatly during inflammation. Urban, J., Chan, D., Schreiber, G. J. Biol. Chem. (1979) [Pubmed]
  2. Relation between pancreatic islet cellular infiltration and plasma fibrinogen or alpha 1-acid glycoprotein levels in spontaneously and streptozotocin-diabetic rats: an increase in these protein levels is not necessary for inducing microcirculatory erythrocyte velocity alteration. Guillot, R., Kassab, J.P., Ogneva, V., André, J., Durussel, J.J., Hadjiisky, P., Peyroux, J., Sternberg, M. Pancreas (1994) [Pubmed]
  3. Effect of turpentine on alpha 1-major acute phase concentration in normal and adrenalectomized rats. Silveira, V.L., Limãos, E.A. Braz. J. Med. Biol. Res. (1990) [Pubmed]
  4. Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells. Gauldie, J., Richards, C., Harnish, D., Lansdorp, P., Baumann, H. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  5. T-kininogen gene expression is induced during aging. Sierra, F., Fey, G.H., Guigoz, Y. Mol. Cell. Biol. (1989) [Pubmed]
  6. Divergent transforming growth factor-beta effects on IL-6 regulation of acute phase plasma proteins in rat hepatoma cells. Campos, S.P., Wang, Y., Koj, A., Baumann, H. J. Immunol. (1993) [Pubmed]
  7. Limited proteolysis of T-kininogen (thiostatin). Release of comparable fragments by different endopeptidases. Moreau, T., Gutman, N., Faucher, D., Gauthier, F. J. Biol. Chem. (1989) [Pubmed]
  8. Structure and expression of the genes for major acute phase alpha 1-protein (thiostatin) and kininogen in the rat. Fung, W.P., Schreiber, G. J. Biol. Chem. (1987) [Pubmed]
  9. The relationship between rat major acute phase protein and the kininogens. Anderson, K.P., Heath, E.C. J. Biol. Chem. (1985) [Pubmed]
  10. Primary structures of the mRNAs encoding the rat precursors for bradykinin and T-kinin. Structural relationship of kininogens with major acute phase protein and alpha 1-cysteine proteinase inhibitor. Furuto-Kato, S., Matsumoto, A., Kitamura, N., Nakanishi, S. J. Biol. Chem. (1985) [Pubmed]
  11. Discrimination between rat thiostatin (T-kininogen) and one of its cystatin-like inhibitory fragments by a monoclonal antibody, and localization of the epitope. Lalmanach, G., Adam, A., Moreau, T., Gutman, N., Gauthier, F. Eur. J. Biochem. (1991) [Pubmed]
  12. Rat major acute-phase protein: biosynthesis and characterization of cDNA clone. Anderson, K.P., Martin, A.D., Heath, E.C. Arch. Biochem. Biophys. (1984) [Pubmed]
  13. Proteins of rat serum IV. Time-course of acute-phase protein expression and its modulation by indomethacine. Eberini, I., Miller, I., Zancan, V., Bolego, C., Puglisi, L., Gemeiner, M., Gianazza, E. Electrophoresis (1999) [Pubmed]
  14. Role of carbohydrate in rat plasma thiostatin: deglycosylation destroys cysteine proteinase inhibition activity. Rusiniak, M.E., Bedi, G.S., Back, N. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  15. The carbohydrate structure of the asparagine-linked oligosaccharides of rat plasma thiostatin. Rusiniak, M.E., Bedi, G.S., Back, N. Biochim. Biophys. Acta (1994) [Pubmed]
  16. Cobalamin (vitamin B12)-deficiency-induced changes in the proteome of rat cerebrospinal fluid. Gianazza, E., Veber, D., Eberini, I., Buccellato, F.R., Mutti, E., Sironi, L., Scalabrino, G. Biochem. J. (2003) [Pubmed]
  17. Expression of the alpha 2-macroglobulin-encoding gene in rat brain and cultured astrocytes. Higuchi, M., Ito, T., Imai, Y., Iwaki, T., Hattori, M., Kohsaka, S., Niho, Y., Sakaki, Y. Gene (1994) [Pubmed]
  18. Effect of aseptic abscesses in protein-deficient rats on the relationship between interleukin-6 and the acute-phase protein, alpha 2-macroglobulin. Jennings, G., Cruickshank, A.M., Shenkin, A., Wight, D.G., Elia, M. Clin. Sci. (1992) [Pubmed]
  19. Identification of estrogen regulated genes in Fe33 rat hepatoma cells by differential display polymerase chain reaction and their hormonal regulation in rat liver and uterus. Diel, P., Walter, A., Fritzemeier, K.H., Hegele-Hartung, C., Knauthe, R. J. Steroid Biochem. Mol. Biol. (1995) [Pubmed]
  20. Purification and characterization of acute phase rat plasma thiostatin. Rusiniak, M.E., Wagh, P.V., Bedi, G.S., Back, N. Prep. Biochem. (1994) [Pubmed]
  21. Major acute-phase alpha(1)protein in the rat: structure, molecular cloning, and regulation of mRNA levels. Cole, T., Inglis, A., Nagashima, M., Schreiber, G. Biochem. Biophys. Res. Commun. (1985) [Pubmed]
  22. Comparison of CO2 laser, electrocautery, and scalpel incisions on acute-phase reactants in rat skin. Johnson, M.A., Gadacz, T.R., Pfeifer, E.A., Given, K.S., Gao, X. The American surgeon. (1997) [Pubmed]
  23. Synthesis of thiostatins (major acute-phase alpha 1 proteins) in different strains of Rattus norvegicus. Cole, T., Schreiber, G. Comp. Biochem. Physiol., B (1989) [Pubmed]
WikiGenes - Universities