Regulation of bone sialoprotein mRNA by steroid hormones.
In this report we demonstrate an increase in the steady-state level of bone sialoprotein ( BSP) mRNA in rat calvaria and a rat osteosarcoma cell line (ROS 17/2.8) after treatment with the synthetic glucocorticoid, dexamethasone. In contrast, 1.25-dihydroxyvitamin D3 reduced the amount of BSP mRNA in calvaria and inhibited the dexamethasone induction in ROS 17/2.8 cells. The increase in BSP mRNA is most likely due to an increase in the transcriptional rate. The stability of mRNA was unchanged after dexamethasone treatment with a half-life of approximately 5 h. Nuclear transcription experiments with nuclei isolated from ROS 17/2.8 cells showed an increased BSP mRNA synthesis in cells treated with dexamethasone.[1]References
- Regulation of bone sialoprotein mRNA by steroid hormones. Oldberg, A., Jirskog-Hed, B., Axelsson, S., Heinegård, D. J. Cell Biol. (1989) [Pubmed]
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