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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Processing of the polymeric immunoglobulin receptor.

The transcellular transport of polymeric immunoglobulins (pIg) across mucosal epithelia is mediated by a membrane glycoprotein known as the polymeric immunoglobulin receptor (pIgR). The intracellular routing of the pIgR has been used as a model to study protein traffic. Examination of the biosynthesis and processing of the pIgR in mammary gland and liver have led to a working hypothesis for pIgR routing in the cell. These hypotheses are currently being tested in an immortalized cell line derived from rabbit mammary gland alveolar cells.[1]


  1. Processing of the polymeric immunoglobulin receptor. Solari, R., Schaerer, E., Tallichet, C., Racine, L., Kraehenbuhl, J.P. Biochem. Soc. Symp. (1989) [Pubmed]
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