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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Bioactivity of human pancreastatin and its localization in pancreas.

Synthetic human pancreastatin and its C-terminal fragment were first evaluated with respect to the biological activity on the insulin secretion in the isolated rat islets. Both these pancreastatins inhibited glucose-stimulated insulin secretion at a concentration of 100 nM. The relative molar potency of human pancreastatin compared to that of porcine pancreastatin was equivalent. The pancreastatin-reactive cells were widely located in the islets of Langerhans, and not observed in exocrine acinar cells by immunocytochemistry using human pancreastatin C-terminal specific antibody. These results suggest that human pancreastatin may modulate endocrine function of the pancreas, especially insulin secretion.[1]


  1. Bioactivity of human pancreastatin and its localization in pancreas. Funakoshi, A., Jimi, A., Yasunami, Y., Tateishi, K., Funakoshi, S., Tamamura, H., Yajima, H. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
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