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Gene Review

CHGA  -  chromogranin A (parathyroid secretory...

Sus scrofa

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Disease relevance of CHGA


High impact information on CHGA


Biological context of CHGA


Anatomical context of CHGA


Associations of CHGA with chemical compounds


Regulatory relationships of CHGA


Other interactions of CHGA

  • It remains to be determined if the changes in transcription of the PTH and CgA genes and stability of their respective mRNAs are direct effects of pancreastatin or secondary actions due to the inhibition of secretion [10].

Analytical, diagnostic and therapeutic context of CHGA


  1. Pancreastatin increases free cytosolic Ca2+ in rat hepatocytes, involving both pertussis-toxin-sensitive and -insensitive mechanisms. Sánchez-Margalet, V., Lucas, M., Goberna, R. Biochem. J. (1993) [Pubmed]
  2. Novel peptide pancreastatin: its occurrence and codistribution with chromogranin A in the central nervous system of the pig. Kar, S., Bretherton-Watt, D., Gibson, S.J., Steel, J.H., Gentleman, S.M., Roberts, G.W., Valentino, K., Tatemoto, K., Ghatei, M.A., Bloom, S.R. J. Comp. Neurol. (1989) [Pubmed]
  3. Plasma pancreastatin-like immunoreactivity correlates with plasma norepinephrine levels in essential hypertension. Sánchez-Margalet, V., Valle, M., Lobón, J.A., Escobar-Jiménez, F., Pérez-Cano, R., Goberna, R. Neuropeptides (1995) [Pubmed]
  4. Pancreastatin inhibits insulin secretion and exocrine pancreatic secretion in the pig. Ahrén, B., Pierzynowski, S.G., Weström, B., Karlsson, B. Diabetes Res. (1990) [Pubmed]
  5. Effect of porcine pancreastatin on endocrine function of canine pancreas. Ohneda, A., Koizumi, F., Ohneda, M. Tohoku J. Exp. Med. (1989) [Pubmed]
  6. Isolation and primary structure of tumor-derived peptides related to human pancreastatin and chromogranin A. Schmidt, W.E., Siegel, E.G., Kratzin, H., Creutzfeldt, W. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  7. Molecular cloning and primary structure of human chromogranin A (secretory protein I) cDNA. Helman, L.J., Ahn, T.G., Levine, M.A., Allison, A., Cohen, P.S., Cooper, M.J., Cohn, D.V., Israel, M.A. J. Biol. Chem. (1988) [Pubmed]
  8. The primary structure of human chromogranin A and pancreastatin. Konecki, D.S., Benedum, U.M., Gerdes, H.H., Huttner, W.B. J. Biol. Chem. (1987) [Pubmed]
  9. Porcine pancreastatin has no effect on endocrine secretion from the pig pancreas. Holst, J.J., Ostenson, C.G., Harling, H., Messell, T. Diabetologia (1990) [Pubmed]
  10. Pancreastatin, a chromogranin A-derived peptide, inhibits transcription of the parathyroid hormone and chromogranin A genes and decreases the stability of the respective messenger ribonucleic acids in parathyroid cells in culture. Zhang, J.X., Fasciotto, B.H., Darling, D.S., Cohn, D.V. Endocrinology (1994) [Pubmed]
  11. The sequence of porcine chromogranin A messenger RNA demonstrates chromogranin A can serve as the precursor for the biologically active hormone, pancreastatin. Iacangelo, A.L., Fischer-Colbrie, R., Koller, K.J., Brownstein, M.J., Eiden, L.E. Endocrinology (1988) [Pubmed]
  12. Glycogenolytic effect of pancreastatin in isolated rat hepatocytes is mediated by a cyclic-AMP-independent Ca(2+)-dependent mechanism. Sánchez, V., Lucas, M., Calvo, J.R., Goberna, R. Biochem. J. (1992) [Pubmed]
  13. Pancreastatin action in the liver: dual coupling to different G proteins. Sánchez-Margalet, V., Lucas, M., Goberna, R. Cell. Signal. (1996) [Pubmed]
  14. Pancreastatin-like immunoreactivity and insulin are released in parallel from the perfused porcine pancreas. Ostenson, C.G., Efendic, S., Holst, J.J. Endocrinology (1989) [Pubmed]
  15. Autocrine regulation of parathyroid secretion: inhibition of secretion by chromogranin-A (secretory protein-I) and potentiation of secretion by chromogranin-A and pancreastatin antibodies. Fasciotto, B.H., Gorr, S.U., Bourdeau, A.M., Cohn, D.V. Endocrinology (1990) [Pubmed]
  16. Localization of pancreastatin immunoreactivity in porcine endocrine cells. Ravazzola, M., Efendic, S., Ostenson, C.G., Tatemoto, K., Hutton, J.C., Orci, L. Endocrinology (1988) [Pubmed]
  17. Pancreastatin: molecular and immunocytochemical characterization of a novel peptide in porcine and human tissues. Schmidt, W.E., Siegel, E.G., Lamberts, R., Gallwitz, B., Creutzfeldt, W. Endocrinology (1988) [Pubmed]
  18. Bioactivity of human pancreastatin and its localization in pancreas. Funakoshi, A., Jimi, A., Yasunami, Y., Tateishi, K., Funakoshi, S., Tamamura, H., Yajima, H. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  19. Immunoassays for measurement of chromogranin A and pancreastatin-like immunoreactivity in humans: correspondence in patients with neuroendocrine neoplasia. Syversen, U., Jacobsen, M.B., O'Connor, D.T., Rønning, K., Waldum, H.L. Neuropeptides (1994) [Pubmed]
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