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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Lack of effect of dietary factors on nicarbazin toxicity in broiler chicks.

Effects of dietary fat, protein, and methionine levels and the type of dietary grain in nicarbazin-containing diets on the growth response of broiler chicks were evaluated in five experiments in a factorial design. Nicarbazin at levels ranging from 100 to 200 mg/kg significantly (P less than .05) depressed weight gain and feed efficiency. Feed intake was significantly reduced only when nicarbazin was used at levels of 150 and 200 mg/kg. The latter concentration also significantly decreased water intake and water:feed ratio. Nicarbazin, at a level of 150 mg/kg, did not affect dietary metabolizable energy content or the retention of nitrogen and dry matter. A higher level of soybean oil (3.5 vs. .5 or 1.0%) did not counteract the growth-depressing effects of 100, 150, and 200 mg nicarbazin/kg. The growth-depressing effect of the highest dose also was not affected by increasing the protein level from 18.2 to 20.4%. Neither type of dietary grains (corn vs. sorghum) nor supplemental methionine level affected the toxicity of 125 mg nicarbazin/kg. Water intake and water:feed ratio were significantly increased due to elevation of dietary protein and fat levels. It was concluded that the severity of the growth-depressing effect of nicarbazin on chicks was not dependent on the levels of dietary unsaturated fat, protein, and methionine.[1]

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