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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Drinking

  • Therefore, there are specific impairments of water intake in response to hypertonicity and hypovolemia in aged MW rats, but Ang-related drinking is not reduced [1].
  • While DHEA treatments did not block either the direct cytotoxic action of SZ on beta-cells or the development of insulitis, the steroid significantly moderated the severity of the ensuing diabetes (reduced hyperglycemia and water consumption, and increased plasma insulin and numbers of residual, granulated beta-cells [2].
  • Body weight, water intake, urine output, solute and urea excretion, serum and urine osmolality, serum creatinine, 24-h creatinine clearance, and fractional excretion of sodium were comparable among the three groups [3].
  • DOCA-salt rats failed to gain weight with markedly increased water intake and decreased food intake; drug treatment did not alter these parameters [4].
  • 2. These studies show that cumulative sodium balance and aldosterone secretion rates in patients with SIADH are negatively correlated with water intake [5].

Psychiatry related information on Drinking


High impact information on Drinking

  • Demeclocycline (600 to 1200 mg daily) restored serum sodium concentration to 139 +/- 1.1 meq per liter within five to 14 days, permitting unrestricted water intake in all patients [11].
  • Pairing lithium chloride with stimulation of the amygdala had no effect on subsequent water intake in the absence of brain stimulation [12].
  • Subjects receiving this pairing greatly reduced their water intake in a retention test, in a similar manner to a group in which saccharin was paired with poisoning [12].
  • Cerebroventricular infusion of P-113, the blocking agent of angiotensin II, into rats for 75 minutes prior to their being allowed to drink, significantly attenuated their water intake when they had been deprived of water for 30 hours [13].
  • Neither intravenous D-glucose nor water intake enhanced MSA [14].

Chemical compound and disease context of Drinking


Biological context of Drinking


Anatomical context of Drinking

  • Now, roles have been established for the apelin system in lowering blood pressure, as a potent cardiac inotrope, in modulating pituitary hormone release and food and water intake, in stress activation, and as a novel adipokine that is excreted from fat cells and regulates insulin [25].
  • Intracerebroventricular (third ventricle) infusion of 1.0 or 2.0 nmol of ANF in conscious, overnight-dehydrated rats significantly inhibited subsequent water intake over a 2-hr test period [26].
  • These results indicate a possible physiologic role for ANF in the hypothalamic control of water intake and reveal that the cardiac peptides can act centrally, as well as peripherally, to assist in the normalization of extracellular fluid volume [26].
  • The activation of neurons in the subfornical organ (SFO) by angiotensin II (AngII) is well established and is widely regarded as the basis for the AngII-induced increase in water intake [27].
  • OBJECTIVE: To determine whether discontinuation of insulin therapy and glucose monitoring and instructions to increase dietary salt and water intake after pancreas transplantation (PTX) resulted in changes in food choices [28].

Associations of Drinking with chemical compounds

  • Normal or increased durations of PS were observed after intravenous (i.v.) administration of vasopressin but also when the normal daily water intake (240 ml) was infused i.v. These results provide direct evidence that PS deficits in the HODI rat are not due to the absence of vasopressin [29].
  • While on ad lib. water intake, the urine flow, urine osmolality, urinary excretion of Na +, K +, creatinine, or total solute excretion did not change [30].
  • In the control rats only water intake was stimulated in response to the induced hyperosmolality, but in the rAOT-treated rats hypertonic mannitol caused a robust salt appetite as well as thirst [31].
  • Chronically, this can be accomplished with increased salt and water intake in conjunction with fludrocortisone [32].
  • NE had no effect on water intake at any age [33].

Gene context of Drinking


Analytical, diagnostic and therapeutic context of Drinking


  1. Differential effects of aging on fluid intake in response to hypovolemia, hypertonicity, and hormonal stimuli in Munich Wistar rats. McKinley, M.J., Denton, D.A., Thomas, C.J., Woods, R.L., Mathai, M.L. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. Therapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice. Coleman, D.L., Leiter, E.H., Schwizer, R.W. Diabetes (1982) [Pubmed]
  3. Urinary concentrating defect in hypothyroid rats: role of sodium, potassium, 2-chloride co-transporter, and aquaporins. Cadnapaphornchai, M.A., Kim, Y.W., Gurevich, A.K., Summer, S.N., Falk, S., Thurman, J.M., Schrier, R.W. J. Am. Soc. Nephrol. (2003) [Pubmed]
  4. Reversal of cardiac fibrosis in deoxycorticosterone acetate-salt hypertensive rats by inhibition of the renin-angiotensin system. Brown, L., Duce, B., Miric, G., Sernia, C. J. Am. Soc. Nephrol. (1999) [Pubmed]
  5. The syndrome of inappropriate antidiuretic hormone secretion (SIADH): pathophysiologic mechanisms in solute and volume regulation. Cooke, C.R., Turin, M.D., Walker, W.G. Medicine (Baltimore) (1979) [Pubmed]
  6. Reduced thirst after water deprivation in healthy elderly men. Phillips, P.A., Rolls, B.J., Ledingham, J.G., Forsling, M.L., Morton, J.J., Crowe, M.J., Wollner, L. N. Engl. J. Med. (1984) [Pubmed]
  7. Brain aromatase and 5alpha-reductase, regulatory behaviors and testosterone levels in adult rats on phytoestrogen diets. Weber, K.S., Jacobson, N.A., Setchell, K.D., Lephart, E.D. Proc. Soc. Exp. Biol. Med. (1999) [Pubmed]
  8. Effect of Losartan, a nonpeptide angiotensin II receptor antagonist, on drinking behavior and renal actions of centrally administered renin. Barbella, Y., Cierco, M., Israel, A. Proc. Soc. Exp. Biol. Med. (1993) [Pubmed]
  9. Effects of dopaminergic agents on alcohol consumption by rats in a limited access paradigm. Linseman, M.A. Psychopharmacology (Berl.) (1990) [Pubmed]
  10. Effects of food deprivation on water intake induced by intermittent delivery of salted liquid food. Picker, M., Soard, G., Poling, A. Physiol. Behav. (1983) [Pubmed]
  11. Superiority of demeclocycline over lithium in the treatment of chronic syndrome of inappropriate secretion of antidiuretic hormone. Forrest, J.N., Cox, M., Hong, C., Morrison, G., Bia, M., Singer, I. N. Engl. J. Med. (1978) [Pubmed]
  12. Electrical stimulation of the amygdala as a conditioned stimulus in a bait-shyness paradigm. Phillips, A.G., LePiane, F.G. Science (1978) [Pubmed]
  13. Angiotensin: physiological role in water-deprivation-induced thirst of rats. Malvin, R.L., Mouw, D., Vander, A.J. Science (1977) [Pubmed]
  14. Sympathetic response to oral carbohydrate administration. Evidence from microelectrode nerve recordings. Berne, C., Fagius, J., Niklasson, F. J. Clin. Invest. (1989) [Pubmed]
  15. Renal denervation prevents and reverses hyperinsulinemia-induced hypertension in rats. Huang, W.C., Fang, T.C., Cheng, J.T. Hypertension (1998) [Pubmed]
  16. Cerebral blood flow and metabolic responses to sustained hypercapnia in awake sheep. Yang, S.P., Krasney, J.A. J. Cereb. Blood Flow Metab. (1995) [Pubmed]
  17. Design of a synthetic leptin agonist: effects on energy balance, glucose homeostasis, and thermoregulation. Rozhavskaya-Arena, M., Lee, D.W., Leinung, M.C., Grasso, P. Endocrinology (2000) [Pubmed]
  18. Different effects of continuous infusion of interleukin-1 and interleukin-6 on the hypothalamic-hypophysial-thyroid axis. van Haasteren, G.A., van der Meer, M.J., Hermus, A.R., Linkels, E., Klootwijk, W., Kaptein, E., van Toor, H., Sweep, C.G., Visser, T.J., de Greef, W.J. Endocrinology (1994) [Pubmed]
  19. Nonosmotic release of vasopressin and renal aquaporins in impaired urinary dilution in hypothyroidism. Chen, Y.C., Cadnapaphornchai, M.A., Yang, J., Summer, S.N., Falk, S., Li, C., Wang, W., Schrier, R.W. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  20. The renin-angiotensin-aldosterone system in congestive failure in conscious dogs. Watkins, L., Burton, J.A., Haber, E., Cant, J.R., Smith, F.W., Barger, A.C. J. Clin. Invest. (1976) [Pubmed]
  21. Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior. Stanley, B.G., Leibowitz, S.F. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  22. Neonatal angiotensin-converting enzyme inhibition in the rat induces persistent abnormalities in renal function and histology. Guron, G., Adams, M.A., Sundelin, B., Friberg, P. Hypertension (1997) [Pubmed]
  23. Comparison of the doubly labeled water (2H2(18)O) method with indirect calorimetry and a nutrient-balance study for simultaneous determination of energy expenditure, water intake, and metabolizable energy intake in preterm infants. Roberts, S.B., Coward, W.A., Schlingenseipen, K.H., Nohria, V., Lucas, A. Am. J. Clin. Nutr. (1986) [Pubmed]
  24. Long-term regulation of urea transporter expression by vasopressin in Brattleboro rats. Shayakul, C., Smith, C.P., Mackenzie, H.S., Lee, W.S., Brown, D., Hediger, M.A. Am. J. Physiol. Renal Physiol. (2000) [Pubmed]
  25. Unravelling the roles of the apelin system: prospective therapeutic applications in heart failure and obesity. Lee, D.K., George, S.R., O'dowd, B.F. Trends Pharmacol. Sci. (2006) [Pubmed]
  26. Atrial natriuretic factor inhibits dehydration- and angiotensin II-induced water intake in the conscious, unrestrained rat. Antunes-Rodrigues, J., McCann, S.M., Rogers, L.C., Samson, W.K. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  27. Electrophysiological and immunocytochemical evidence for a cGMP-mediated inhibition of subfornical organ neurons by nitric oxide. Rauch, M., Schmid, H.A., deVente, J., Simon, E. J. Neurosci. (1997) [Pubmed]
  28. Diet after pancreas transplantation. Markowski, D.M., Larsen, J.L., McElligott, M.C., Walter, G.A., Miller, S.A., Frisbie, K., Stratta, R.J. Diabetes Care (1996) [Pubmed]
  29. Sleep deficits in rats with hereditary diabetes insipidus. Danguir, J. Nature (1983) [Pubmed]
  30. Chlorpropamide action on renal concentrating mechanism in rats with hypothalamic diabetes insipidus. Kusano, E., Braun-Werness, J.L., Vick, D.J., Keller, M.J., Dousa, T.P. J. Clin. Invest. (1983) [Pubmed]
  31. Central oxytocin inhibition of salt appetite in rats: evidence for differential sensing of plasma sodium and osmolality. Blackburn, R.E., Samson, W.K., Fulton, R.J., Stricker, E.M., Verbalis, J.G. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  32. Effects of volume loading and pressor agents in idiopathic orthostatic tachycardia. Jacob, G., Shannon, J.R., Black, B., Biaggioni, I., Mosqueda-Garcia, R., Robertson, R.M., Robertson, D. Circulation (1997) [Pubmed]
  33. The arousal of ingestive behaviors by chemical injection into the brain of the suckling rat. Ellis, S., Axt, K., Epstein, A.N. J. Neurosci. (1984) [Pubmed]
  34. Glucagon-like peptides. Drucker, D.J. Diabetes (1998) [Pubmed]
  35. Chronic blockade of the melanocortin 4 receptor subtype leads to obesity independently of neuropeptide Y action, with no adverse effects on the gonadotropic and somatotropic axes. Raposinho, P.D., Castillo, E., d'Alleves, V., Broqua, P., Pralong, F.P., Aubert, M.L. Endocrinology (2000) [Pubmed]
  36. Moderate alcohol consumption increases cholesterol efflux mediated by ABCA1. Beulens, J.W., Sierksma, A., van Tol, A., Fournier, N., van Gent, T., Paul, J.L., Hendriks, H.F. J. Lipid Res. (2004) [Pubmed]
  37. Insulin-like growth factor (IGF)-1 and IGF-binding protein-1 concentrations in serum of normal subjects after alcohol ingestion: evidence for decreased IGF-1 bioavailability. Röjdmark, S., Rydvald, Y., Aquilonius, A., Brismar, K. Clin. Endocrinol. (Oxf) (2000) [Pubmed]
  38. Vasopressin increases glomerular filtration rate in conscious rats through its antidiuretic action. Bouby, N., Ahloulay, M., Nsegbe, E., Déchaux, M., Schmitt, F., Bankir, L. J. Am. Soc. Nephrol. (1996) [Pubmed]
  39. Possible dual effect of endogenous ANP on water and sodium intake and role of AII. Franci, C.R. Neuroscience and biobehavioral reviews. (1997) [Pubmed]
  40. Qualitative differences in polysaccharide and sugar tastes in the rat: a two-carbohydrate taste model. Nissenbaum, J.W., Sclafani, A. Neuroscience and biobehavioral reviews. (1987) [Pubmed]
  41. The effect of captopril on sodium appetite in adrenalectomized and deoxycorticosterone-treated rats. Elfont, R.M., Fitzsimons, J.T. J. Physiol. (Lond.) (1985) [Pubmed]
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