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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Lymphocyte ecto-5'-nucleotidase deficiency in agammaglobulinemia.

Fresh peripheral blood lymphocytes from eight patients with congenital agammaglobulinemia demonstrate reduced ecto-5'-nucleotidase activity when compared to the mean activity of normal subjects and patients with other forms of immunoglobulin deficiency. A specific defect of ecto-5'-nucleotidase is further suggested by normal values for lymphocyte ecto-adenosinetriphosphatase and ecto-nonspecific phosphatase. The data provide evidence for an enzyme deficiency in this X-linked, B lymphocyte deficiency syndrome.[1]


  1. Lymphocyte ecto-5'-nucleotidase deficiency in agammaglobulinemia. Edwards, N.L., Magilavy, D.B., Cassidy, J.T., Fox, I.H. Science (1978) [Pubmed]
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