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Gene Review

NT5E  -  5'-nucleotidase, ecto (CD73)

Homo sapiens

Synonyms: 5'-NT, 5'-nucleotidase, CALJA, CD73, E5NT, ...
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Disease relevance of NT5E


High impact information on NT5E


Chemical compound and disease context of NT5E


Biological context of NT5E


Anatomical context of NT5E


Associations of NT5E with chemical compounds


Enzymatic interactions of NT5E

  • 5'-Nucleotidase (5'-NT) dephosphorylates cladribine-MP and the accumulation of cladribine-TP depends on the ratio of dCK and 5'-NT in the cells [23].

Co-localisations of NT5E

  • We hypothesize that an E-NPP is co-localized with an ecto-nucleoside triphosphate diphosphohydrolase and an ecto-5'-nucleotidase on the platelet surface, as part of a multiple system for nucleotide hydrolysis, since they can act under distinct physiological conditions and can be differently regulated [24].

Regulatory relationships of NT5E


Other interactions of NT5E

  • The differences in PNP (P less than 0.05) and in 5'NT (P less than 0.01) between these two groups were significant [29].
  • A similar shift towards heavier cytoskeletal fractions also took place with other proteins coexpressed with ecto-5'-nucleotidase, such as alphav, alpha5, beta1 and beta3-integrins, caveolin-1 and CD44 [2].
  • CD161+ T (NT) cells exist predominantly in human intestinal epithelium as well as in liver [30].
  • It has been suggested that increased ADA and 5'NT together with decreased GUA activities might be a physiologic attempt of the cancer cells to provide more substrates needed by cancer cells to accelerate the salvage pathway activity [31].
  • ADA and 5'NT activities were found increased and that of the XO decreased in the cancerous tissues relative to non cancerous ones [32].

Analytical, diagnostic and therapeutic context of NT5E


  1. Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. Synnestvedt, K., Furuta, G.T., Comerford, K.M., Louis, N., Karhausen, J., Eltzschig, H.K., Hansen, K.R., Thompson, L.F., Colgan, S.P. J. Clin. Invest. (2002) [Pubmed]
  2. Expression of ecto-5'-nucleotidase (eN, CD73) in cell lines from various stages of human melanoma. Sadej, R., Spychala, J., Skladanowski, A.C. Melanoma Res. (2006) [Pubmed]
  3. Patterns of adenosine deaminase, ecto-5'-nucleotidase, poly(A)polymerase and surface light chain expression in chronic lymphocytic leukemias. Trangas, T., Courtis, N., Gounaris, A., Perez, S., Kokkinopoulos, D., Pangalis, G.A., Tsiapalis, C.M. Blut (1989) [Pubmed]
  4. Adenosine deaminase and ecto-5'-nucleotidase activities in various leukemias with special reference to blast crisis: significance of ecto-5'-nucleotidase in lymphoid blast crisis of chronic myeloid leukemia. Koya, M., Kanoh, T., Sawada, H., Uchino, H., Ueda, K. Blood (1981) [Pubmed]
  5. Deoxyribonucleoside triphosphate accumulation by leukemic cells. Mitchell, B.S., Edwards, N.L., Koller, C.A. Blood (1983) [Pubmed]
  6. Lymphocyte ecto-5'-nucleotidase deficiency in agammaglobulinemia. Edwards, N.L., Magilavy, D.B., Cassidy, J.T., Fox, I.H. Science (1978) [Pubmed]
  7. Molecular approach to adenosine receptors: receptor-mediated mechanisms of tissue protection. Linden, J. Annu. Rev. Pharmacol. Toxicol. (2001) [Pubmed]
  8. Neutrophil-derived 5'-adenosine monophosphate promotes endothelial barrier function via CD73-mediated conversion to adenosine and endothelial A2B receptor activation. Lennon, P.F., Taylor, C.T., Stahl, G.L., Colgan, S.P. J. Exp. Med. (1998) [Pubmed]
  9. CD73 is involved in lymphocyte binding to the endothelium: characterization of lymphocyte-vascular adhesion protein 2 identifies it as CD73. Airas, L., Hellman, J., Salmi, M., Bono, P., Puurunen, T., Smith, D.J., Jalkanen, S. J. Exp. Med. (1995) [Pubmed]
  10. Serum catalase as marker of graft-vs-host disease in allogeneic bone marrow transplant recipients: pilot study. Yasmineh, W.G., Kaur, T.P., Blazar, B.R., Theologides, A. Clin. Chem. (1995) [Pubmed]
  11. Isolation and characterization of the promoter of the human 5'-nucleotidase (CD73)-encoding gene. Hansen, K.R., Resta, R., Webb, C.F., Thompson, L.F. Gene (1995) [Pubmed]
  12. Concanavalin A inhibition of ecto-5'-nucleotidase of intact cultured C6 glioma cells. Stefanovic, V., Mandel, P., Rosenberg, A. J. Biol. Chem. (1975) [Pubmed]
  13. Properties of the Group IV phospholipase A(2) family. Ghosh, M., Tucker, D.E., Burchett, S.A., Leslie, C.C. Prog. Lipid Res. (2006) [Pubmed]
  14. Differential regulation and function of CD73, a glycosyl-phosphatidylinositol-linked 70-kD adhesion molecule, on lymphocytes and endothelial cells. Airas, L., Niemelä, J., Salmi, M., Puurunen, T., Smith, D.J., Jalkanen, S. J. Cell Biol. (1997) [Pubmed]
  15. IFN-alpha induced adenosine production on the endothelium: a mechanism mediated by CD73 (ecto-5'-nucleotidase) up-regulation. Niemelä, J., Henttinen, T., Yegutkin, G.G., Airas, L., Kujari, A.M., Rajala, P., Jalkanen, S. J. Immunol. (2004) [Pubmed]
  16. Ecto-5'-nucleotidase of intact cultured C6 rat glioma cells. Stefanovic, V., Mandel, P., Rosenberg, A. J. Biol. Chem. (1976) [Pubmed]
  17. Ecto-enzyme and signaling functions of lymphocyte CD73. Resta, R., Yamashita, Y., Thompson, L.F. Immunol. Rev. (1998) [Pubmed]
  18. Differential gene expression by integrin beta 7+ and beta 7- memory T helper cells. Rodriguez, M.W., Paquet, A.C., Yang, Y.H., Erle, D.J. BMC Immunol. (2004) [Pubmed]
  19. Regulation of ecto-5'-nucleotidase by TNF-alpha in human endothelial cells. Kalsi, K., Lawson, C., Dominguez, M., Taylor, P., Yacoub, M.H., Smolenski, R.T. Mol. Cell. Biochem. (2002) [Pubmed]
  20. Ion-exchange column chromatographic method for assaying purine metabolic pathway enzymes. Ward, H., Baldwin, D., Wang, T., Warner, H., Seymour, K., Marquardt, C., McFalls, E., Foker, J.E. J. Chromatogr. B Biomed. Sci. Appl. (1998) [Pubmed]
  21. Surface expression, polarization, and functional significance of CD73 in human intestinal epithelia. Strohmeier, G.R., Lencer, W.I., Patapoff, T.W., Thompson, L.F., Carlson, S.L., Moe, S.J., Carnes, D.K., Mrsny, R.J., Madara, J.L. J. Clin. Invest. (1997) [Pubmed]
  22. Biochemical correlates of the differential sensitivity of subtypes of human leukemia to deoxyadenosine and deoxycoformycin. Matsumoto, S.S., Yu, A.L., Bleeker, L.C., Bakay, B., Kung, F.H., Nyhan, W.L. Blood (1982) [Pubmed]
  23. Pharmacological basis for cladribine resistance. Lotfi, K., Juliusson, G., Albertioni, F. Leuk. Lymphoma (2003) [Pubmed]
  24. Ecto-nucleotide pyrophosphatase/phosphodiesterase as part of a multiple system for nucleotide hydrolysis by platelets from rats: kinetic characterization and biochemical properties. Fürstenau, C.R., Trentin, D.d.a. .S., Barreto-Chaves, M.L., Sarkis, J.J. Platelets (2006) [Pubmed]
  25. The human liver contains multiple populations of NK cells, T cells, and CD3+CD56+ natural T cells with distinct cytotoxic activities and Th1, Th2, and Th0 cytokine secretion patterns. Doherty, D.G., Norris, S., Madrigal-Estebas, L., McEntee, G., Traynor, O., Hegarty, J.E., O'Farrelly, C. J. Immunol. (1999) [Pubmed]
  26. Activation of adenosine receptor on gingival fibroblasts. Hashikawa, T., Takedachi, M., Terakura, M., Yamada, S., Thompson, L.F., Shimabukuro, Y., Murakami, S. J. Dent. Res. (2006) [Pubmed]
  27. Overexpression of ecto-5'-nucleotidase promotes P-glycoprotein expression in renal epithelial cells. Ledoux, S., Leroy, C., Siegfried, G., Prie, D., Moullier, P., Friedlander, G. Kidney Int. (1997) [Pubmed]
  28. Parathyroid hormone stimulates ecto-5'-nucleotidase activity in renal epithelial cells: role of protein kinase-C. Siegfried, G., Vrtovsnik, F., Prié, D., Amiel, C., Friedlander, G. Endocrinology (1995) [Pubmed]
  29. Purine degradative enzymes and immunological phenotypes in chronic B-lymphocytic leukaemia: indications that leukaemic immunocytoma is a separate entity. Ho, A.D., Dörken, B., Ma, D.D., Pezzutto, A., Hunstein, W., Hoffbrand, A.V. Br. J. Haematol. (1986) [Pubmed]
  30. CD161+ T (NT) cells exist predominantly in human intestinal epithelium as well as in liver. Iiai, T., Watanabe, H., Suda, T., Okamoto, H., Abo, T., Hatakeyama, K. Clin. Exp. Immunol. (2002) [Pubmed]
  31. Activities of adenosine deaminase, 5'-nucleotidase, guanase, and cytidine deaminase enzymes in cancerous and non-cancerous human breast tissues. Canbolat, O., Durak, I., Cetin, R., Kavutcu, M., Demirci, S., Oztürk, S. Breast Cancer Res. Treat. (1996) [Pubmed]
  32. Effects of black grape extract on activities of DNA turn-over enzymes in cancerous and non cancerous human colon tissues. Durak, I., Cetin, R., Devrim, E., Ergüder, I.B. Life Sci. (2005) [Pubmed]
  33. Human monocyte derived dendritic cells express functional P2X and P2Y receptors as well as ecto-nucleotidases. Berchtold, S., Ogilvie, A.L., Bogdan, C., Mühl-Zürbes, P., Ogilvie, A., Schuler, G., Steinkasserer, A. FEBS Lett. (1999) [Pubmed]
  34. CD73 mediates adhesion of B cells to follicular dendritic cells. Airas, L., Jalkanen, S. Blood (1996) [Pubmed]
  35. Regulation of endothelial CD73 by adenosine: paracrine pathway for enhanced endothelial barrier function. Narravula, S., Lennon, P.F., Mueller, B.U., Colgan, S.P. J. Immunol. (2000) [Pubmed]
  36. Involvement of CD73 (ecto-5'-nucleotidase) in adenosine generation by human gingival fibroblasts. Hashikawa, T., Takedachi, M., Terakura, M., Saho, T., Yamada, S., Thompson, L.F., Shimabukuro, Y., Murakami, S. J. Dent. Res. (2003) [Pubmed]
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