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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The gene for enhancer binding proteins E12/E47 lies at the t(1;19) breakpoint in acute leukemias.

The gene (E2A) that codes for proteins with the properties of immunoglobulin enhancer binding factors E12/E47 was mapped to chromosome region 19p13.2-p13.3, a site associated with nonrandom translocations in acute lymphoblastic leukemias. The majority of t(1;19)(q23;p13)-carrying leukemias and cell lines studied contained rearrangements of E2A as determined by DNA blot analyses. The rearrangements altered the E2A transcriptional unit, resulting in the synthesis of a transcript larger than the normal-sized E2A mRNAs in one of the cell lines with this translocation. These observations indicate that the gene for a transcription factor is located at the breakpoint of a consistently recurring chromosomal translocation in many acute leukemias and suggest a direct role for alteration of such factors in the pathogenesis of some malignancies.[1]


  1. The gene for enhancer binding proteins E12/E47 lies at the t(1;19) breakpoint in acute leukemias. Mellentin, J.D., Murre, C., Donlon, T.A., McCaw, P.S., Smith, S.D., Carroll, A.J., McDonald, M.E., Baltimore, D., Cleary, M.L. Science (1989) [Pubmed]
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