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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Identification of a novel metabolite in phenanthrene metabolism by the fungus Cunninghamella elegans.

The metabolism of phenanthrene by the fungus Cunninghamella elegans was investigated. Kinetic experiments using [9-14C]phenanthrene showed that after 72 h, 53% of the total radioactivity was associated with a glucoside conjugate of 1-hydroxyphenanthrene (phenanthrene 1-O-beta-glucose). This metabolite was isolated by reversed-phase high-performance liquid chromatography and characterized by the application of UV absorption, 1H nuclear magnetic resonance, and mass spectral techniques. The results show that aromatic ring oxidation followed by glucosylation is a predominant pathway in the metabolism of the polycyclic aromatic hydrocarbon phenanthrene by C. elegans.[1]

References

  1. Identification of a novel metabolite in phenanthrene metabolism by the fungus Cunninghamella elegans. Cerniglia, C.E., Campbell, W.L., Freeman, J.P., Evans, F.E. Appl. Environ. Microbiol. (1989) [Pubmed]
 
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