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Disease relevance of Cunninghamella


High impact information on Cunninghamella


Biological context of Cunninghamella


Anatomical context of Cunninghamella


Associations of Cunninghamella with chemical compounds


Gene context of Cunninghamella

  • The filamentous fungus Cunninghamella utilizes cytochrome P450 system(s) in the metabolism of a broad range of polyaromatic and aliphatic pollutants and a variety of drugs, but prior attempts at isolation of P450 system components of this fungus have been generally unsuccessful [17].
  • Microbial models of mammalian metabolism. N-dealkylation of furosemide to yield the mammalian metabolite CSA using Cunninghamella elegans [18].
  • All strains of Cunninghamella tested accumulated metabolite M4 = EMD 46193 ([4-(2-hydroxy-3-isopropylaminopropoxy)benzyloxy]ethanol) [19].
  • Molecular polymerase chain reaction diagnosis of pulmonary mucormycosis caused by Cunninghamella bertholletiae [20].


  1. Fungal metabolism and detoxification of polycyclic aromatic hydrocarbons. Cerniglia, C.E., White, G.L., Heflich, R.H. Arch. Microbiol. (1985) [Pubmed]
  2. Microbial metabolism of phenelzine and pheniprazine. Foster, B.C., Coutts, R.T., Pasutto, F.M., Mozayani, A. Life Sci. (1988) [Pubmed]
  3. Microbial reduction of 1-(4-fluorophenyl)-4-[4-(5-fluoro-2-pyrimidinyl)-1- piperazinyl]butan-1-one. Patel, R.N., Banerjee, A., Liu, M., Hanson, R., Ko, R., Howell, J., Szarka, L.J. Biotechnol. Appl. Biochem. (1993) [Pubmed]
  4. A fatal case of disseminated zygomycosis associated with the use of blood glucose self-monitoring equipment. Hampson, F.G., Ridgway, E.J., Feeley, K., Reilly, J.T. J. Infect. (2005) [Pubmed]
  5. Identification and sequencing of a cDNA encoding 6-phosphogluconate dehydrogenase from a fungus, Cunninghamella elegans and expression of the gene in Escherichia coli. Wang, R.F., Khan, A.A., Cao, W.W., Cerniglia, C.E. FEMS Microbiol. Lett. (1998) [Pubmed]
  6. Metabolism of xenobiotic compounds by enzymes in cell extracts of the fungus Cunninghamella elegans. Wackett, L.P., Gibson, D.T. Biochem. J. (1982) [Pubmed]
  7. Fungal metabolism of biphenyl. Dodge, R.H., Cerniglia, C.E., Gibson, D.T. Biochem. J. (1979) [Pubmed]
  8. Transformation of verapamil by Cunninghamella blakesleeana. Sun, L., Huang, H.H., Liu, L., Zhong, D.F. Appl. Environ. Microbiol. (2004) [Pubmed]
  9. Biotransformation of malachite green by the fungus Cunninghamella elegans. Cha, C.J., Doerge, D.R., Cerniglia, C.E. Appl. Environ. Microbiol. (2001) [Pubmed]
  10. Purification, characterization and complete amino acid sequence of nuclease C1 from Cunninghamella echinulata var. echinulata. Ho, H.C., Shiau, P.F., Liu, F.C., Chung, J.G., Chen, L.Y. Eur. J. Biochem. (1998) [Pubmed]
  11. Microbial hydroxylation of bufalin by Cunninghamella blakesleana and Mucor spinosus. Ye, M., Han, J., Tu, G., An, D., Guo, D. J. Nat. Prod. (2005) [Pubmed]
  12. Protoplast release from fungi capable of steroid transformation. Długoński, J., Sedlaczek, L., Jaworski, A. Can. J. Microbiol. (1984) [Pubmed]
  13. Metabolism of naphthalene by Cunninghamella elegans. Cerniglia, C.E., Gibson, D.T. Appl. Environ. Microbiol. (1977) [Pubmed]
  14. Identification of a novel metabolite in phenanthrene metabolism by the fungus Cunninghamella elegans. Cerniglia, C.E., Campbell, W.L., Freeman, J.P., Evans, F.E. Appl. Environ. Microbiol. (1989) [Pubmed]
  15. Biotransformation of chlorpromazine and methdilazine by Cunninghamella elegans. Zhang, D., Freeman, J.P., Sutherland, J.B., Walker, A.E., Yang, Y., Cerniglia, C.E. Appl. Environ. Microbiol. (1996) [Pubmed]
  16. Transformation of 1- and 2-methylnaphthalene by Cunninghamella elegans. Cerniglia, C.E., Lambert, K.J., Miller, D.W., Freeman, J.P. Appl. Environ. Microbiol. (1984) [Pubmed]
  17. Cloning and characterization of the cytochrome P450 oxidoreductase gene from the zygomycete fungus Cunninghamella. Yadav, J.S., Loper, J.C. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  18. Microbial models of mammalian metabolism. N-dealkylation of furosemide to yield the mammalian metabolite CSA using Cunninghamella elegans. Hezari, M., Davis, P.J. Drug Metab. Dispos. (1992) [Pubmed]
  19. Microbial metabolism of the beta-adrenoreceptor antagonist bisoprolol. Schwartz, H., Licht, R.E., Radunz, H.E. Appl. Microbiol. Biotechnol. (1993) [Pubmed]
  20. Molecular polymerase chain reaction diagnosis of pulmonary mucormycosis caused by Cunninghamella bertholletiae. Kobayashi, M., Togitani, K., Machida, H., Uemura, Y., Ohtsuki, Y., Taguchi, H. Respirology (2004) [Pubmed]
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