Disease relevance of Cunninghamella

• The mutagenic activity of ethyl acetate extracts of culture medium from Cunninghamella elegans incubated 72 h with various polycyclic aromatic hydrocarbons (PAHs) was evaluated in the Salmonella typhimurium reversion assay [1].
• Phenelzine and pheniprazine were used as substrates for metabolic studies with Cunninghamella echinulata and Mycobacterium smegmatis [2].
• In contrast, Lactobacillus kefir (A.T.C.C. 35411), Pullularia pullulans (A.T.C.C. 16623), Trigonopsis variabilis (A.T.C.C. 10679) and Cunninghamella echinulata (A.T.C.C. 26269) reduced compound 1 to the (S)-(-)-alcohol (2) [3].
• We report a fatal case of disseminated zygomycosis due to Cunninghamella bertholletiae in a 68-year-old man with myelodysplasia and type II diabetes mellitus, receiving desferrioxamine therapy for iron overload secondary to multiple transfusions [4].
• Identification and sequencing of a cDNA encoding 6-phosphogluconate dehydrogenase from a fungus, Cunninghamella elegans and expression of the gene in Escherichia coli [5].

High impact information on Cunninghamella

• Cell extracts of the filamentous fungus Cunninghamella elegans contain epoxide hydrolase (EC 3.3.2.3), glutathione S-transferase (EC 2.5.1.18) and UDP-glucuronosyltransferase (EC 2.4.1.17) activities [6].
• Cunninghamella elegans grown on Sabouraud dextrose broth transformed biphenyl to produce 2-, 3- and 4-hydroxybiphenyl, as well as 4,4'-dihydroxybiphenyl as free phenols [7].
• Transformation of verapamil by Cunninghamella blakesleeana [8].
• Biotransformation of malachite green by the fungus Cunninghamella elegans [9].
• The filamentous fungus Cunninghamella elegans ATCC 36112 metabolized the triphenylmethane dye malachite green with a first-order rate constant of 0.029 micromol x h(-1) (mg of cells)(-1) [9].

Biological context of Cunninghamella

• Purification, characterization and complete amino acid sequence of nuclease C1 from Cunninghamella echinulata var. echinulata [10].
• Microbial hydroxylation of bufalin by Cunninghamella blakesleana and Mucor spinosus [11].

Anatomical context of Cunninghamella

• Protoplasts were obtained from Hyphoderma roseum (Fries) and Cunninghamella elegans (Lendner), fungi capable of steroid 11-hydroxylation [12].

Associations of Cunninghamella with chemical compounds

• Cunninghamella elegans grown on Sabouraud dextrose broth in the presence of naphthalene produced six metabolites [13].
• Metabolism of naphthalene by Cunninghamella elegans [13].
• The metabolism of phenanthrene by the fungus Cunninghamella elegans was investigated [14].
• When tested as a microbial model for mammalian drug metabolism, the filamentous fungus Cunninghamella elegans metabolized chlorpromazine and methdilazine within 72 h [15].
• Transformation of 1- and 2-methylnaphthalene by Cunninghamella elegans [16].

Gene context of Cunninghamella

• The filamentous fungus Cunninghamella utilizes cytochrome P450 system(s) in the metabolism of a broad range of polyaromatic and aliphatic pollutants and a variety of drugs, but prior attempts at isolation of P450 system components of this fungus have been generally unsuccessful [17].
• Microbial models of mammalian metabolism. N-dealkylation of furosemide to yield the mammalian metabolite CSA using Cunninghamella elegans [18].
• All strains of Cunninghamella tested accumulated metabolite M4 = EMD 46193 ([4-(2-hydroxy-3-isopropylaminopropoxy)benzyloxy]ethanol) [19].
• Molecular polymerase chain reaction diagnosis of pulmonary mucormycosis caused by Cunninghamella bertholletiae [20].

References