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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Prevalence of antibodies to rotavirus in different age-groups of infants in Bochum, West Germany.

We studied the prevalence of antibody to rotavirus in 386 serum samples obtained from different age-groups of infants in Bochum, West Germany. Cord sera mirrored the IgG titer and serotype specificity of the corresponding maternal sera. IgG antibody prevalence decreased with age, reached a minimum between four and 12 months, and increased thereafter. IgM antibodies appeared first in the eight- to 12-month age-group, and IgM prevalence remained high thereafter. The serum level of IgA was low in all age-groups. Significant prevalence increases with increasing age were observed for neutralizing antibodies to rotavirus serotypes 1 and 3. Antibodies to serotype 4 had not reached adult level at 2.5 y of age. Prevalence of antibodies to serotype 2 was low in all age-groups. The percentage of monospecific sera neutralizing only one serotype was high in young infants eight to 12 months of age and decreased significantly with increasing age.[1]

References

  1. Prevalence of antibodies to rotavirus in different age-groups of infants in Bochum, West Germany. Brüssow, H., Werchau, H., Liedtke, W., Lerner, L., Mietens, C., Sidoti, J., Sotek, J. J. Infect. Dis. (1988) [Pubmed]
 
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