Disease relevance of CORD1

• METHODS: Cord blood from infants of HIV-seropositive women in Durban, South Africa, were tested for in vitro reactivity to a cocktail of HIV envelope peptides (Env) using a bioassay measuring interleukin-2 production in a murine cell line [1].
• Compared to a cohort of 147 patients admitted to the Midwest Regional Spinal Cord Injury Care System during the time period of the study, subjects were more likely to have paraplegia, incomplete sensory myelopathy, gunshot wounds to the spine and non-surgical spinal stabilization [2].
• We studied the prevalence of antibody to rotavirus in 386 serum samples obtained from different age-groups of infants in Bochum, West Germany. Cord sera mirrored the IgG titer and serotype specificity of the corresponding maternal sera [3].
• From 1981 to 1986, 13 patients with quadriplegia at the New England Regional Model Spinal Cord Injury Center had caval interruption with a Greenfield filter [4].
• CONCLUSION: Cord blood hematopoietic progenitor cell concentration was higher in male infants, even after correcting for birth weight [5].

Psychiatry related information on CORD1

• PURPOSE: To develop and conduct a preliminary assessment of the content validity, test-retest reliability, and convergent validity of the Physical Activity Recall Assessment for People with Spinal Cord Injury (PARA-SCI), a new physical activity measure for people with SCI [6].
• This paper provides a review of PTSD and Spinal Cord Injuries [7].
• OBJECTIVES: This article reviews literature examining the psychological adjustment to Spinal Cord Injury (SCI) and illustrates the applicability of a Stress Appraisal and Coping model (SAC) for rehabilitation of this population [8].

High impact information on CORD1

• BACKGROUND: Cord-blood banks have increased the use of cord-blood transplantation in patients with hematologic disorders [9].
• CONCLUSIONS: Cord blood is a feasible alternative source of hematopoietic stem cells for pediatric and some adult patients with major hematologic disorders, particularly if the donor and the recipient are related [9].
• A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study [10].
• PARTICIPANTS: Individuals with expertise in anthropology, blood banking, bone marrow transplantation, ethics, law, obstetrics, pediatrics, and the social sciences were invited to join the Working Group on Ethical Issues in Umbilical Cord Blood Banking [11].
• Ethical issues in umbilical cord blood banking. Working Group on Ethical Issues in Umbilical Cord Blood Banking [11].

Chemical compound and disease context of CORD1

• Frankel scores were used to assess outcome (P < 0.05) and were assessed at admission and at the time of definitive discharge from the Spinal Cord Injury Care System. The hypothesis that methylprednisolone therapy significantly improves functional outcomes in patients with gunshot wound injuries to the spine was rejected [12].
• Finally, total recombinant hepatitis B surface antigen production was higher on Cord 1014 than on polystyrene and DF samples [13].
• METHODS: Cord (fetal) and maternal blood were obtained at delivery from control subjects (n = 33) and women with gestational diabetes (n = 40) and analysed for plasma triglycerides and cholinephosphoglycerides, and erythrocyte choline- and ethanolaminephosphoglycerides fatty acids [14].
• SETTING: Two inpatient rehabilitation programs, one pediatric and one adult, in the Northwest Regional Spinal Cord Injury System. PATIENTS: Patients with acute SCI who developed immobilization hypercalcemia that was treated with pamidronate [15].
• BACKGROUND: Cord blood lactate at birth is a marker of antenatal hypoxia, and is comparable to pH as a prognostic tool [16].

Biological context of CORD1

• We suggest that CRD1 provides a novel mechanism through which p300 and CBP can switch activities between the promoters of genes that stimulate growth and those that enhance cell cycle arrest [17].
• Rather, we describe a previously uncharacterized transcriptional repression domain (CRD1) within p300. p300 transactivation is stimulated through derepression of CRD1 by p21 [17].
• RESULTS: Cord plasma phospholipid gamma-linolenic acid and dihomo- gamma-linolenic acid concentrations were negatively related to insulin concentrations and calculated insulin resistance (homeostasis model assessment) at seven years of age [18].
• RESEARCH DESIGNS AND METHODS: Maori and Pacific Island mothers were prospectively recruited at Middlemore Hospital, South Auckland. Cord blood was taken from umbilical vein at birth from singleton babies born after 32 weeks of gestation to 138 mothers with GDM, 39 mothers with type 2 diabetes, and 95 control mothers [19].
• RESEARCH DESIGN AND METHODS: Cord blood sera from 1,118 subjects from the Diabetes Autoimmunity Study in the Young (DAISY) cohort, as well as their venous blood samples taken at follow-up clinic visits, were tested for GAD65 autoantibodies (GAAs), insulin autoantibodies (IAAs), and IA-2 autoantibodies (IA-2As) [20].

Anatomical context of CORD1

• METHODS: Cord blood-derived human (h)MCs maintained in stem cell factor (SCF) alone were compared with replicates treated with IL-4, IL-5, or IL-9, respectively, for their patterns of FcepsilonRI-dependent gene induction using microarray technology [21].
• Characterization of banked umbilical cord blood hematopoietic progenitor cells and lymphocyte subsets and correlation with ethnicity, birth weight, sex, and type of delivery: a Cord Blood Transplantation (COBLT) Study report [22].
• CONCLUSION: Cord blood-derived human cultured mast cells constitutively express mRNA for TGF-beta1 and produce functional TGF-beta1 [23].
• Strategies for modifying axonal growth, synaptic function, and recovery of neural function after injury to the central nervous system: a conference report. National Spinal Cord Injury Association and the Society for Neuroscience. May 10-12, 1985, Fort Lauderdale, Florida [24].
• Transplantation of Fibroblasts that Overexpress Matrix Metalloproteinase-3 into the Site of Spinal Cord Injury in Rats [25].

Associations of CORD1 with chemical compounds

• The following results were obtained: Cord blood: Clotting tests within age-related normal ranges; PIVKA II detection rates: 0/22 (Xa/ec), 1/22 (CIE), 4/22 (MAB); plasma vitamin K1: undetectable in 20/22 [26].
• METHODS: Cord blood from randomly selected term newborns were analysed for total IgE-antibodies and in vitro SLT-release in response to allergen and anti-IgE stimulation [27].
• Nicotinic Regulation of Calcium/Calmodulin-Dependent Protein Kinase II Activation in the Spinal Cord [28].
• STUDY DESIGN AND METHODS: To clarify the influence of the removal of DMSO by this method on the speed of engraftment in unrelated cord blood transplantation, 46 adult patients with cord blood units processed by the Tokyo Cord Blood Bank from September 1998 to March 31, 2002 were studied [29].
• OBJECTIVE: Cord blood pH, lactate, hypoxanthine, and erythropoietin levels have all been used as markers of either acute or chronic asphyxia [30].

Other interactions of CORD1

• We conclude the mutation is responsible for cord1 and demonstrate that this canine disease is a valuable model for exploring disease mechanisms and potential therapies for human Leber congenital amaurosis [31].
• We mapped the cord1 locus to a region of canine chromosome CFA15 that is syntenic with a region of human chromosome 14 (HSA14q11.2) containing the retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGRIP1) gene [31].
• When 33BDNF.4 and 33V1 cells were transplanted in the lumbar subarachnoid space of the spinal cord 1 week after CCI, they survived greater than 7 weeks on the pia mater around the spinal cord and the 33BDNF.4 cells continued to synthesize BDNF in vivo [32].

Analytical, diagnostic and therapeutic context of CORD1

• METHODS: Cord blood was taken from infants at high risk for having asthma and allergic diseases who were recruited for a primary prevention study in which infants were randomized into the intervention or the control group [33].
• By immunohistochemistry, equivalent numbers of infected cells could be found in the spinal cord 1 week postinfection (p.i.): however, after that time, the number of infected cells in the wild-type virus-infected mice continued to increase, whereas the virus-positive cells from the variant virus-infected mice gradually decreased [34].
• Data of 98 motor complete SCI patients were derived from the European Multicenter Study of Human Spinal Cord Injury database [35].
• BACKGROUND: Cord blood is a useful source of HPCs for allogeneic transplantation [36].
• A retrospective epidemiologic study of renal calculi was conducted on 5,915 patients from the National Spinal Cord Injury Data Research Center data base [37].

References