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Gene Review

CORD1  -  cone rod dystrophy 1 (autosomal dominant)

Homo sapiens

Synonyms: CORD, CRD1
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Disease relevance of CORD1

  • METHODS: Cord blood from infants of HIV-seropositive women in Durban, South Africa, were tested for in vitro reactivity to a cocktail of HIV envelope peptides (Env) using a bioassay measuring interleukin-2 production in a murine cell line [1].
  • Compared to a cohort of 147 patients admitted to the Midwest Regional Spinal Cord Injury Care System during the time period of the study, subjects were more likely to have paraplegia, incomplete sensory myelopathy, gunshot wounds to the spine and non-surgical spinal stabilization [2].
  • We studied the prevalence of antibody to rotavirus in 386 serum samples obtained from different age-groups of infants in Bochum, West Germany. Cord sera mirrored the IgG titer and serotype specificity of the corresponding maternal sera [3].
  • From 1981 to 1986, 13 patients with quadriplegia at the New England Regional Model Spinal Cord Injury Center had caval interruption with a Greenfield filter [4].
  • CONCLUSION: Cord blood hematopoietic progenitor cell concentration was higher in male infants, even after correcting for birth weight [5].

Psychiatry related information on CORD1

  • PURPOSE: To develop and conduct a preliminary assessment of the content validity, test-retest reliability, and convergent validity of the Physical Activity Recall Assessment for People with Spinal Cord Injury (PARA-SCI), a new physical activity measure for people with SCI [6].
  • This paper provides a review of PTSD and Spinal Cord Injuries [7].
  • OBJECTIVES: This article reviews literature examining the psychological adjustment to Spinal Cord Injury (SCI) and illustrates the applicability of a Stress Appraisal and Coping model (SAC) for rehabilitation of this population [8].

High impact information on CORD1


Chemical compound and disease context of CORD1

  • Frankel scores were used to assess outcome (P < 0.05) and were assessed at admission and at the time of definitive discharge from the Spinal Cord Injury Care System. The hypothesis that methylprednisolone therapy significantly improves functional outcomes in patients with gunshot wound injuries to the spine was rejected [12].
  • Finally, total recombinant hepatitis B surface antigen production was higher on Cord 1014 than on polystyrene and DF samples [13].
  • METHODS: Cord (fetal) and maternal blood were obtained at delivery from control subjects (n = 33) and women with gestational diabetes (n = 40) and analysed for plasma triglycerides and cholinephosphoglycerides, and erythrocyte choline- and ethanolaminephosphoglycerides fatty acids [14].
  • SETTING: Two inpatient rehabilitation programs, one pediatric and one adult, in the Northwest Regional Spinal Cord Injury System. PATIENTS: Patients with acute SCI who developed immobilization hypercalcemia that was treated with pamidronate [15].
  • BACKGROUND: Cord blood lactate at birth is a marker of antenatal hypoxia, and is comparable to pH as a prognostic tool [16].

Biological context of CORD1

  • We suggest that CRD1 provides a novel mechanism through which p300 and CBP can switch activities between the promoters of genes that stimulate growth and those that enhance cell cycle arrest [17].
  • Rather, we describe a previously uncharacterized transcriptional repression domain (CRD1) within p300. p300 transactivation is stimulated through derepression of CRD1 by p21 [17].
  • RESULTS: Cord plasma phospholipid gamma-linolenic acid and dihomo- gamma-linolenic acid concentrations were negatively related to insulin concentrations and calculated insulin resistance (homeostasis model assessment) at seven years of age [18].
  • RESEARCH DESIGNS AND METHODS: Maori and Pacific Island mothers were prospectively recruited at Middlemore Hospital, South Auckland. Cord blood was taken from umbilical vein at birth from singleton babies born after 32 weeks of gestation to 138 mothers with GDM, 39 mothers with type 2 diabetes, and 95 control mothers [19].
  • RESEARCH DESIGN AND METHODS: Cord blood sera from 1,118 subjects from the Diabetes Autoimmunity Study in the Young (DAISY) cohort, as well as their venous blood samples taken at follow-up clinic visits, were tested for GAD65 autoantibodies (GAAs), insulin autoantibodies (IAAs), and IA-2 autoantibodies (IA-2As) [20].

Anatomical context of CORD1


Associations of CORD1 with chemical compounds

  • The following results were obtained: Cord blood: Clotting tests within age-related normal ranges; PIVKA II detection rates: 0/22 (Xa/ec), 1/22 (CIE), 4/22 (MAB); plasma vitamin K1: undetectable in 20/22 [26].
  • METHODS: Cord blood from randomly selected term newborns were analysed for total IgE-antibodies and in vitro SLT-release in response to allergen and anti-IgE stimulation [27].
  • Nicotinic Regulation of Calcium/Calmodulin-Dependent Protein Kinase II Activation in the Spinal Cord [28].
  • STUDY DESIGN AND METHODS: To clarify the influence of the removal of DMSO by this method on the speed of engraftment in unrelated cord blood transplantation, 46 adult patients with cord blood units processed by the Tokyo Cord Blood Bank from September 1998 to March 31, 2002 were studied [29].
  • OBJECTIVE: Cord blood pH, lactate, hypoxanthine, and erythropoietin levels have all been used as markers of either acute or chronic asphyxia [30].

Other interactions of CORD1


Analytical, diagnostic and therapeutic context of CORD1

  • METHODS: Cord blood was taken from infants at high risk for having asthma and allergic diseases who were recruited for a primary prevention study in which infants were randomized into the intervention or the control group [33].
  • By immunohistochemistry, equivalent numbers of infected cells could be found in the spinal cord 1 week postinfection (p.i.): however, after that time, the number of infected cells in the wild-type virus-infected mice continued to increase, whereas the virus-positive cells from the variant virus-infected mice gradually decreased [34].
  • Data of 98 motor complete SCI patients were derived from the European Multicenter Study of Human Spinal Cord Injury database [35].
  • BACKGROUND: Cord blood is a useful source of HPCs for allogeneic transplantation [36].
  • A retrospective epidemiologic study of renal calculi was conducted on 5,915 patients from the National Spinal Cord Injury Data Research Center data base [37].


  1. T-helper cell responses to HIV envelope peptides in cord blood: protection against intrapartum and breast-feeding transmission. Kuhn, L., Coutsoudis, A., Moodley, D., Trabattoni, D., Mngqundaniso, N., Shearer, G.M., Clerici, M., Coovadia, H.M., Stein, Z. AIDS (2001) [Pubmed]
  2. Function-limiting dysesthetic pain syndrome among traumatic spinal cord injury patients: a cross-sectional study. Davidoff, G., Roth, E., Guarracini, M., Sliwa, J., Yarkony, G. Pain (1987) [Pubmed]
  3. Prevalence of antibodies to rotavirus in different age-groups of infants in Bochum, West Germany. Brüssow, H., Werchau, H., Liedtke, W., Lerner, L., Mietens, C., Sidoti, J., Sotek, J. J. Infect. Dis. (1988) [Pubmed]
  4. Complications of caval interruption by Greenfield filter in quadriplegics. Balshi, J.D., Cantelmo, N.L., Menzoian, J.O. J. Vasc. Surg. (1989) [Pubmed]
  5. Cord blood hematopoietic progenitor cell concentration and infant sex. Aroviita, P., Teramo, K., Hiilesmaa, V., Kekomäki, R. Transfusion (2005) [Pubmed]
  6. Development and evaluation of an activity measure for people with spinal cord injury. Ginis, K.A., Latimer, A.E., Hicks, A.L., Craven, B.C. Medicine and science in sports and exercise. (2005) [Pubmed]
  7. Post traumatic stress disorder and spinal cord injuries. Kennedy, P., Duff, J. Spinal Cord (2001) [Pubmed]
  8. The impact of coping on emotional adjustment to spinal cord injury (SCI): review of the literature and application of a stress appraisal and coping formulation. Galvin, L.R., Godfrey, H.P. Spinal Cord (2001) [Pubmed]
  9. Outcome of cord-blood transplantation from related and unrelated donors. Eurocord Transplant Group and the European Blood and Marrow Transplantation Group. Gluckman, E., Rocha, V., Boyer-Chammard, A., Locatelli, F., Arcese, W., Pasquini, R., Ortega, J., Souillet, G., Ferreira, E., Laporte, J.P., Fernandez, M., Chastang, C. N. Engl. J. Med. (1997) [Pubmed]
  10. A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study. Bracken, M.B., Shepard, M.J., Collins, W.F., Holford, T.R., Young, W., Baskin, D.S., Eisenberg, H.M., Flamm, E., Leo-Summers, L., Maroon, J. N. Engl. J. Med. (1990) [Pubmed]
  11. Ethical issues in umbilical cord blood banking. Working Group on Ethical Issues in Umbilical Cord Blood Banking. Sugarman, J., Kaalund, V., Kodish, E., Marshall, M.F., Reisner, E.G., Wilfond, B.S., Wolpe, P.R. JAMA (1997) [Pubmed]
  12. Use of methylprednisolone as an adjunct in the management of patients with penetrating spinal cord injury: outcome analysis. Levy, M.L., Gans, W., Wijesinghe, H.S., SooHoo, W.E., Adkins, R.H., Stillerman, C.B. Neurosurgery (1996) [Pubmed]
  13. Cell growth on cordierite: an approach to the identification of reliable supports for continuous-flow solid-bed reactors. Orlandi, L., Solmi, R., Krajewski, A., Bearzatto, A., Biagini, G., Ciccopiedi, E., Ravaglioli, A. Biomaterials (1997) [Pubmed]
  14. Fetal erythrocyte membrane lipids modification: preliminary observation of an early sign of compromised insulin sensitivity in offspring of gestational diabetic women. Min, Y., Lowy, C., Ghebremeskel, K., Thomas, B., Bitsanis, D., Crawford, M.A. Diabet. Med. (2005) [Pubmed]
  15. Immobilization hypercalcemia treatment with pamidronate disodium after spinal cord injury. Massagli, T.L., Cardenas, D.D. Archives of physical medicine and rehabilitation. (1999) [Pubmed]
  16. Effect of delayed sampling on umbilical cord arterial and venous lactate and blood gases in clamped and unclamped vessels. Armstrong, L., Stenson, B. Archives of disease in childhood. Fetal and neonatal edition. (2006) [Pubmed]
  17. A novel transcriptional repression domain mediates p21(WAF1/CIP1) induction of p300 transactivation. Snowden, A.W., Anderson, L.A., Webster, G.A., Perkins, N.D. Mol. Cell. Biol. (2000) [Pubmed]
  18. Components of the insulin resistance syndrome in seven-year-old children: relations with birth weight and the polyunsaturated fatty acid content of umbilical cord plasma phospholipids. Rump, P., Popp-Snijders, C., Heine, R.J., Hornstra, G. Diabetologia (2002) [Pubmed]
  19. Hyperinsulinemia in cord blood in mothers with type 2 diabetes and gestational diabetes mellitus in New Zealand. Westgate, J.A., Lindsay, R.S., Beattie, J., Pattison, N.S., Gamble, G., Mildenhall, L.F., Breier, B.H., Johnstone, F.D. Diabetes Care (2006) [Pubmed]
  20. Is presence of islet autoantibodies at birth associated with development of persistent islet autoimmunity? The Diabetes Autoimmunity Study in the Young (DAISY). Stanley, H.M., Norris, J.M., Barriga, K., Hoffman, M., Yu, L., Miao, D., Erlich, H.A., Eisenbarth, G.S., Rewers, M. Diabetes Care (2004) [Pubmed]
  21. FcepsilonRI-dependent gene expression in human mast cells is differentially controlled by T helper type 2 cytokines. Lora, J.M., Al-Garawi, A., Pickard, M.D., Price, K.S., Bagga, S., Sicoli, J., Hodge, M.R., Gutiérrez-Ramos, J.C., Briskin, M.J., Boyce, J.A. J. Allergy Clin. Immunol. (2003) [Pubmed]
  22. Characterization of banked umbilical cord blood hematopoietic progenitor cells and lymphocyte subsets and correlation with ethnicity, birth weight, sex, and type of delivery: a Cord Blood Transplantation (COBLT) Study report. Cairo, M.S., Wagner, E.L., Fraser, J., Cohen, G., van de Ven, C., Carter, S.L., Kernan, N.A., Kurtzberg, J. Transfusion (2005) [Pubmed]
  23. Cord blood-derived human cultured mast cells produce transforming growth factor beta1. Kanbe, N., Kurosawa, M., Nagata, H., Saitoh, H., Miyachi, Y. Clin. Exp. Allergy (1999) [Pubmed]
  24. Strategies for modifying axonal growth, synaptic function, and recovery of neural function after injury to the central nervous system: a conference report. National Spinal Cord Injury Association and the Society for Neuroscience. May 10-12, 1985, Fort Lauderdale, Florida. Veraa, R.P., Mendell, L.M. Exp. Neurol. (1986) [Pubmed]
  25. Transplantation of Fibroblasts that Overexpress Matrix Metalloproteinase-3 into the Site of Spinal Cord Injury in Rats. Pizzi, M.A., Crowe, M.J. J. Neurotrauma (2006) [Pubmed]
  26. Des-gamma-carboxyprothrombin (PIVKA II) and plasma vitamin K1 in newborns and their mothers. von Kries, R., Shearer, M.J., Widdershoven, J., Motohara, K., Umbach, G., Göbel, U. Thromb. Haemost. (1992) [Pubmed]
  27. Cord blood leucocytes/basophils produce and release sulfidoleucotrienes in response to allergen stimulation. Szépfalusi, Z., Todoran, L., Elsässer, S., Jagdt, B., Wank, H., Urbanek, R. Clin. Exp. Allergy (1999) [Pubmed]
  28. Nicotinic Regulation of Calcium/Calmodulin-Dependent Protein Kinase II Activation in the Spinal Cord. Damaj, M.I. J. Pharmacol. Exp. Ther. (2007) [Pubmed]
  29. Wash-out of DMSO does not improve the speed of engraftment of cord blood transplantation: follow-up of 46 adult patients with units shipped from a single cord blood bank. Nagamura-Inoue, T., Shioya, M., Sugo, M., Cui, Y., Takahashi, A., Tomita, S., Zheng, Y., Takada, K., Kodo, H., Asano, S., Takahashi, T.A. Transfusion (2003) [Pubmed]
  30. Markers of acute and chronic asphyxia in infants with meconium-stained amniotic fluid. Richey, S.D., Ramin, S.M., Bawdon, R.E., Roberts, S.W., Dax, J., Roberts, J., Gilstrap, L.C. Am. J. Obstet. Gynecol. (1995) [Pubmed]
  31. Canine RPGRIP1 mutation establishes cone-rod dystrophy in miniature longhaired dachshunds as a homologue of human Leber congenital amaurosis. Mellersh, C.S., Boursnell, M.E., Pettitt, L., Ryder, E.J., Holmes, N.G., Grafham, D., Forman, O.P., Sampson, J., Barnett, K.C., Blanton, S., Binns, M.M., Vaudin, M. Genomics (2006) [Pubmed]
  32. Lumbar transplant of neurons genetically modified to secrete brain-derived neurotrophic factor attenuates allodynia and hyperalgesia after sciatic nerve constriction. Cejas, P.J., Martinez, M., Karmally, S., McKillop, M., McKillop, J., Plunkett, J.A., Oudega, M., Eaton, M.J. Pain (2000) [Pubmed]
  33. Umbilical cord blood mononuclear cell proliferative response to house dust mite does not predict the development of allergic rhinitis and asthma. Chan-Yeung, M., Ferguson, A., Chan, H., Dimich-Ward, H., Watson, W., Manfreda, J., Becker, A. J. Allergy Clin. Immunol. (1999) [Pubmed]
  34. A neutralization-resistant Theiler's virus variant produces an altered disease pattern in the mouse central nervous system. Zurbriggen, A., Fujinami, R.S. J. Virol. (1989) [Pubmed]
  35. Fighting for Each Segment: Estimating the Clinical Value of Cervical and Thoracic Segments in SCI. Hedel, H.J., Curt, A. J. Neurotrauma (2006) [Pubmed]
  36. Direct immunomagnetic method for CD34+ cell selection from cryopreserved cord blood grafts for ex vivo expansion protocols. Querol, S., Capmany, G., Azqueta, C., Gabarró, M., Fornas, O., Martín-Henao, G.A., García, J. Transfusion (2000) [Pubmed]
  37. The risk of renal calculi in spinal cord injury patients. DeVivo, M.J., Fine, P.R., Cutter, G.R., Maetz, H.M. J. Urol. (1984) [Pubmed]
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