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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Up-regulatory effect of triphasic oral contraceptive on platelet 3H-imipramine binding sites.

Triphasic oral contraceptive (Logynon) induced a significant increase (36%) in the maximal binding capacity of platelet membranes for [3H]imipramine. The increase was achieved in the second Logynon cycle as compared to pretreatment and first Logynon cycle binding values. The pill contains a combination of ethinyl estradiol and levonorgestrel, and it is as yet unclear which of the two hormones is responsible for the up-regulatory effect. The increase in the density of platelet imipramine binding sites may reflect a similar alteration in brain. The increase in imipramine binding did not correlate with alteration in mood as assessed by Beck Depression Inventory scores.[1]

References

  1. Up-regulatory effect of triphasic oral contraceptive on platelet 3H-imipramine binding sites. Weizman, A., Morgenstern, H., Kaplan, B., Amiri, Z., Tyano, S., Ovadia, Y., Rehavi, M. Psychiatry research. (1988) [Pubmed]
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