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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Exacerbations of multiple sclerosis in patients treated with gamma interferon.

In an open, randomised study, 18 patients with clinically definite, relapsing-remitting multiple sclerosis ( MS) received 1 microgram, 30 micrograms, or 1000 micrograms doses of recombinant gamma interferon (IFN-gamma), given by intravenous infusion twice a week for four weeks. 7 patients had exacerbations during treatment. This exacerbation rate, compared retrospectively with the pretreatment rate and prospectively with the post-treatment rate, was significantly greater than expected. Exacerbations were not precipitated by fever or other dose-dependent side-effects. A concomitant increase in circulating monocytes bearing class II (HLA-DR) surface antigen suggested that the attacks induced during treatment were immunologically mediated. IFN-gamma is unsuitable for treatment of MS.[1]

References

  1. Exacerbations of multiple sclerosis in patients treated with gamma interferon. Panitch, H.S., Hirsch, R.L., Haley, A.S., Johnson, K.P. Lancet (1987) [Pubmed]
 
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