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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Differential regulation of Ultrabithorax in two germ layers of Drosophila.

The homeotic gene Ultrabithorax (Ubx) is expressed in specific parts of Drosophila embryos: in a single metamer in the visceral mesoderm and forming a complex pattern limited to a broad domain in the ectoderm and in the somatic mesoderm. Here we use a linked beta-galactosidase gene to identify cis-acting regulatory sequences. In the visceral mesoderm, correct expression of Ubx depends on localized upstream sequences. In the ectoderm, all galactosidase-positive transformants show the same characteristic pattern. The repeated elements of this basal pattern appear to be a sub-pattern of engrailed (en) expression; they depend on en function as well as on sequences in the Ubx RNA leader. We use a mutant (Haltere-mimic) to show that sequences that normally restrict segmental expression of Ubx in the ectoderm are located downstream from the RNA leader.[1]


  1. Differential regulation of Ultrabithorax in two germ layers of Drosophila. Bienz, M., Saari, G., Tremml, G., Müller, J., Züst, B., Lawrence, P.A. Cell (1988) [Pubmed]
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