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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Loss of matrix calcium-binding protein-containing neurons in Huntington's disease.

In post-mortem brain specimens from patients dying with a clinical diagnosis of Huntington's disease ( HD) immunohistochemistry showed a substantial loss from the neostriatum of neurons containing the calcium- binding protein calbindin 28K. These calbindin neurons, and the straital compartment in which they are sited, are particularly damaged in HD, suggesting that a failure of calcium buffering or homeostasis may contribute to cell death in HD.[1]


  1. Loss of matrix calcium-binding protein-containing neurons in Huntington's disease. Seto-Ohshima, A., Emson, P.C., Lawson, E., Mountjoy, C.Q., Carrasco, L.H. Lancet (1988) [Pubmed]
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